Primary tracheobronchial amyloidosis

Li, D; Shi, Zhihong; Wang, Y; Thakur, Asmitananda

doi:10.4103/0022-3859.118045

Cited by 9 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The symptoms are usually nonspecific, resulting in being misdiagnosed as asthma, recurrent pneumonia, tracheobronchitis, or COPD. The average life expectancy for PTBA is approximately 9 years, and the overall survival rate at 4–6 years is only 31–43% [ 17 ]. Due to airway obstruction, patients often develops post-obstructive pneumonia and respiratory failure [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The average life expectancy for PTBA is approximately 9 years, and the overall survival rate at 4–6 years is only 31–43% [ 17 ]. Due to airway obstruction, patients often develops post-obstructive pneumonia and respiratory failure [ 17 ]. Therefore, early diagnosis of this disease is critical to improve the prognosis of patients.…”

Section: Discussionmentioning

confidence: 99%

“…However CT chest transverse section may be normal in 50% of patients with PTBA [ 17 ]. CT Chest coronal section may show diffuse multiple polypoid nodules in the trachea and main bronchi, termed as “wavy path sign”, which might precede those of the transverse section findings and may be more characteristic [ 17 ]. Chest radiography is normal in up to 70% of patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary endobronchial amyloidosis: A rare case of endobronchial tumor

Lal

Akhtar

Khan

et al. 2018

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

Primary localized endobronchial amyloidosis is a rare entity, as pulmonary amyloidosis most commonly occurs as a part of systemic AL amyloidosis. It can be asymptomatic or can present with nonspecific symptoms such as progressive dyspnea, cough, wheezing and rarely respiratory failure. It is frequently misdiagnosed as asthma, COPD or pneumonia. Solitary endobronchial amyloidosis having a nodular appearance can mimic endobronchial tumor. The diagnosis is usually delayed by 8–37 months. The average life expectancy for primary tracheobronchial amyloidosis is approximately 9 years, so the early diagnosis of this disease is very critical to improve the prognosis of patients. We are presenting a case of 65 year old male which was initially diagnosed and treated as asthma exacerbation with minimal improvement. Further workup was done with CT chest, bronchoscopy and biopsy because of persistent shortness of breath, which revealed primary localized solitary endobronchial amyloidosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary endobronchial amyloidosis: A rare case of endobronchial tumor

Lal

Akhtar

Khan

et al. 2018

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…On computer tomography, diffuse TBA leads to concentric smooth or nodular thickening of the submucosal tracheal wall. The diagnosis of TBA is made by means of bronchoscopy and biopsy of airway mucosa [1,7,8] .…”

Section: Introductionmentioning

confidence: 99%

Multifocal primary amyloidosis of the airways: Case report and review of the literature

Lang

Täuscher

Fuller

et al. 2015

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

Primary localized amyloidosis of the airways is an uncommon disorder characterized by amyloid deposits in the airway mucosa. In contrast to systemic amyloidosis other organs are not involved. Among the entities of airway amyloidosis, tracheobronchial amyloidosis is comparatively the most common subtype in the lower respiratory tract and laryngeal amyloidosis in the upper respiratory tract. The pathophysiology of localized airway amyloidosis is poorly understood. The clinical presentation is variable and often non-specific. No general consensus exists with regard to optimal treatment resulting in a variety of modalities used in clinical practice to manage this disorder. We report the case of a 50 year old woman with multifocal localized amyloidosis of the tracheobronchial tree and the upper airways. Tracheobronchial amyloidosis was treated with endoscopic debulking and external beam radiation, sinunasal amyloid deposits were surgically excised and are currently under surveillance. The importance of this extremely rare case lies in the multifocal presentation of an uncommon disorder requiring a multidisciplinary approach to offer optimal treatment including external beam radiation.

show abstract

“…[ 1 ] Various factors have been implicated in its etiology, including sarcoidosis, warfarin use, tracheobronchopathia osteochondroplastica generally manifesting with nodular calcifications, relapsing polychondritis, amyloidosis, and advanced age. [ 2 3 ] Respiratory symptoms related to airway stenosis may occur, such as hemoptysis and dyspnea, or the condition may be completely asymptomatic. Our patient did not have a history of pulmonary disease or respiratory complaints.…”

mentioning

confidence: 99%