2018
DOI: 10.20944/preprints201811.0095.v1
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Primary Tree Shrew Dermis Fibroblasts Support Lytic Replication of Human Cytomegalovirus

Abstract: As a universal pathogen leading to neonatal defects and transplant failure, Human cytomegalovirus (HCMV) has strict species specificity that the inability to using this virus in animals has hampered its pathogenesis study. However, the mechanism of cross-species barrier remains elusive that no non-human cell model has been established to fill this knowledge gap. We observed that primary dermis fibroblasts (TSDF) isolated from the Chinese tree shrew (Tupaia belangeri chinensis), a small laboratory animal with c… Show more

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