Primary tumor prevalence has an impact on the constituent ratio of metastases to the jaw but not on metastatic sites

Abstract

This article provides an overview of metastases to jaws (MJ), mainly concerning the differences between American and Chinese patients, and exploring the relationship between the primary tumors' prevalence (PTP) and constituent ratio of MJ. Information concerning of 399 MJ cases in 215 papers, including one new case in our hospital, was subjected to statistic analysis. The main clinical features of MJ, such as constituent ratio of PTP and that of MJ, metastatic sites, treatments, and prognosis were summarized. Breast, lung, kidney, prostate and thyroid (in descending order) were the leading primary sites of MJ. Furthermore, the constituent ratio of MJ was found to be correlated with that of PTP in all subjects including American and Chinese subjects in our study. As to metastatic sites in the mandible, a specific "M" shaped pattern appeared regardless of the tumor type or constituent ratios of MJ were in all subjects. Almost all subjects received traditionally palliative treatments, and the prognosis was quite poor. The PTP had a significant impact on the constituent ratio of MJ. However, it was the properties of the microenvironment rather than characteristics or constituent ratios of tumor cells, that decided the metastatic sites in various tumor subjects.

Metastatic gastric tube cancer detected in a resected mandibular bone with osteoradionecrosis

“… 2,3 The ramus and the molar region are the favoured metastatic sites in the mandibular bone. Zhang et al 3 suggested that good vascularization of the jaw bone increased the risk of metastasis.…”

Primary intraosseous squamous cell carcinoma of the mandible

“…Çene kemiğine metastaz yapan primer tümör alanları temelde meme, akciğer, böbrek, prostat ve tiroid bezidir. [6] Bu nedenle hastamızın geçmişinde meme kanseri öyküsü olması nedeniyle lezyonun öncelikle metastatik olabileceği düşünülerek PET-BT incelemesi yapıldı. Biyopsi ve cerrahi yöntemle alınan örneğin histopatolojik incelemesi sonucu meme karsinomu metastazı ile uyumlu olmayan hastanın PET-BT incelemesinde de ek patoloji saptanmayınca metastatik hastalık olasılığı ekarte edildi.…”

Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

“…The latest studies were included in the analyses to avoid double citation. In addition, two extensive series were not included since they did not meet the study criteria and it was impossible to identify whether their series included solely lung carcinomas in their series [7,8]. The collected data was added to the data published in M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT the previous study in which the literature was searched from 1916 to 2006 [6].…”