Primary upper small-intestinal lymphoma

Nasr, Khosrow; Haghighi, Parviz; Bakhshandeh, Kiumars; Abadi, P; Lahimgarzadeh, A.

doi:10.1007/bf01071844

Cited by 25 publications

(3 citation statements)

References 40 publications

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“…The lymphoma spreads to mesenteric, paraaortic, and retroperitoneal nodes, and to other parts of the gastrointestinal tract. Spread to superficial nodes, liver, spleen, and bone marrow occurs late [47,50]. The histological nature of the lymphoma of IPSID has been confused by the usual problems with classification and by the inclusion of Western type lymphomas in series of Mediterranean lymphomasr Most, if not all, of the lymphomas of IPSID are immunoblastic with plasmacytoid features [46,47], and r chains may be shown in better differentiated lymphoma cells by immunocytochemistry [46].…”

Section: Pathological Findingsmentioning

confidence: 99%

Small intestinal lymphoma

Cooper

Read

1985

World j. surg.

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This paper reviews small intestinal lymphoma. Although a major emphasis is placed on primary small intestinal lymphoma of the “Western” type, the important topic of lymphoma in celiac disease is discussed. Our own recent experience of 7 patients with lymphoma in celiac disease is presented. The lymphoma of immunoproliferative small intestinal disease (“Mediterranean” lymphoma) and the associated α‐chain disease are also reviewed, with emphasis on the differences from the “Western” type of primary small intestinal lymphoma.

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Section: Pathological Findingsmentioning

confidence: 99%

Small intestinal lymphoma

Cooper

Read

1985

World j. surg.

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“…Laboratory work-up usually demonstrates evidence of malabsorption and malnutrition in most patients, especially those with long-standing disease. Thus, impaired absorption of fat and d-xylose, protein-losing enteropathy, hypoalbuminemia, and hypokalemia are present in the majority of patients with advanced disease [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Stool examination shows parasitic infestation in about one-third of the patients, which in my own experience, is not significantly different from that observed in age and socioeconomically matched hospital patients without intestinal tumor [ 121.…”

Section: Laboratory Abnormalitiesmentioning

confidence: 99%

Primary lymphomas of the small intestine: East‐west contrast

Al‐Mondhiry

1986

American J Hematol

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Primary small intestinal lymphoma (PSIL) represents a heterogenous group of disorders with variable clinical and pathologic features and a characteristic age, socioeconomic, and geographic distribution. In developed countries, PSIL usually occurs as a localized ileal tumor, shows a bimodal age distribution, and most frequently presents with abdominal pain and obstructive symptoms. Histologically, most of these tumors are diffuse histiocytic, lymphocytic, or undifferentiated lymphomas. Other variants of PSIL, collectively referred to as immunoproliferative small intestinal disease, occur most often among young patients of poor socioeconomic status in Third World countries, mostly in the Middle East and Mediterranean area. They are characterized by involvement of long loops of the upper small intestine and commonly present with abdominal pain, diarrhea, malabsorption, and clubbing of the fingers. A subgroup of these patients shows a serological abnormality with the appearance of part of the alpha heavy chain of IgA in the serum. Histologically, the lesion appears as a dense diffuse lymphoplasmacytic infiltrate of the mucosa of the upper jejenum or duodenum. A form of malignant lymphoma of true histiocytic origin complicates long-standing celiac disease. The contrasting clinical, epidemiological, histopathological, and immunological features of these variants of PSIL raise interesting questions about the pathogenesis of small bowel lymphoma.

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“…The majority of IPSID cases have come from Israel [1,2], northern Africa [15,28,29], and other middle eastern and Mediterranean countries [30][31][32]. However, the disease is not confined to this particular geographical area, as numerous cases have been reported from the Indian subcontinent, the Far East, central and sub-Saharian Africa, and central and south America [26,32].…”

Section: Introductionmentioning

confidence: 99%

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Economidou¹,

Manousos²,

Triantafillidis³

et al. 2006

European Journal of Gastroenterology & Hepatology

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The patients were categorized in three subgroups of IPSID: alpha-chain disease (n=8), non-alpha chain disease with other monoclonal immunoglobulins (n=3), and polyclonal 'non-malignant' IPSID (n=2). In several patients the disease had unusual features, and this in some cases delayed the diagnosis. In suspected cases it is thus of the utmost importance to proceed to an exploratory laparatomy. Patients with stage C disease had a short survival, whereas two patients with stage A alpha-chain disease responded to treatment with cyclophosphamide, vincristine and prednisolone, and cyclophosphamide, doxorubicine, vincristine and prednisolone, respectively, have a disease-free long survival of 35 and 12 years, and appear to be cured.

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Primary upper small-intestinal lymphoma

Cited by 25 publications

References 40 publications

Small intestinal lymphoma

Small intestinal lymphoma

Primary lymphomas of the small intestine: East‐west contrast

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

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