Primary vaginal adenosarcoma with sarcomatous overgrowth

Toyoshima, Masafumi; Akahira, Jun Ichi; Moriya, Takuya; Hayakawa, Seiichirou; Yaegashi, Nobuo

doi:10.1016/j.ygyno.2004.08.004

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…Tumor markers were reported in 13/41 (31.7%) patients, two patients had normal value [ 20 , 31 ] and 11 patients had elevated value [ 12 , 15 , 17 , 18 , 23 , 24 , 27 , 30 , 32 – 34 ] (Table 1 ). Seven of eleven (63.6%) patients had elevated serum levels of CA 125 [ 12 , 15 , 18 , 23 , 27 , 30 , 32 ], 2/11 (18.2%) patients had elevated serum levels of both CA 125 and CA 19–9 [ 17 , 34 ], 1/11 (9.1%) patient had elevated serum levels of both CA125 and CEA [ 24 ], 1/11 (9.1%) had elevated serum level of LDH [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Endometriosis treatment was not reported for 18/25 (72%) patients [5c,10,11,15,17,19abc,23,24,26,30,31,33,36,37,38], endometriosis was surgically and hormonally treated in 2/25 (8%) patients [ 29 , 39 ], it was treated surgically in 3/25 (12%) patients [ 21 , 25 , 27 ], it was treated hormonally (aromatase inhibitor) in 1/25 (4%) patient [ 22 ], and it was treated with surgery, hormonal therapy and brachytherapy in 1/25 (4%) patient [ 16 ]. Overall, 17/25 (68%) patients with endometriosis had an AS with extra-genital localization [5c-10-11-17-19abc-22-23-24-29-30-31-33-36-37-38], and 8/25 (32%) patients had a vaginally localized tumour [15–16–21-25-26-27-32-39].…”

Section: Resultsmentioning

confidence: 99%

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Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

et al. 2018

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BackgroundExtra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours’ histological characteristics and sites of origin. The best treatment and oncologic outcome have not been clarified because only a few cases of extra-uterine and extra-ovarian adenosarcoma have been described in the literature. Here, we report a case of primary peritoneal adenosarcoma with sarcomatous overgrowth and review all reported cases of adenosarcomas arising outside of the uterus and outside the ovaries to identify the best treatment options and clarify outcomes.Case presentationA 79-year-old woman was referred to our Department with an abdominal mass resembling a fibroid with a haemorrhage. Her gynaecological history was negative. A transvaginal and transabdominal ultrasound examination revealed a multicystic mass resembling an ovarian tumour arising from the pelvis and extending up to the abdomen. At laparotomy a peritoneal mass arising from Douglas peritoneum was resected. The uterus and adnexa appeared normal, and a supra-cervical hysterectomy with bilateral salpingo-oophorectomy was performed. No macroscopic residual disease was present. Final pathology diagnosed a malignant peripheral nerve sheath tumors with divergent differentiation. Four weeks later a new, multicystic mass was found. Due to the progressive poor condition, the patient died four months after diagnosis. Histological slides were reviewed by external expert pathologists and the final diagnosis was of extra-genital adenosarcoma with sarcomatous overgrowth. Furthermore, we also collected and analysed articles written in English regarding extra-uterine and extra-ovarian adenosarcomas published between January 1974 and October 2016. PubMed was used as a database for this search. Clinical and pathological characteristics, treatments and outcomes were assessed.ConclusionsOnly 41 cases has been reported in literature. Previous endometriosis and sarcomatous overgrowth showed an inverse effect on prognosis. Endometriosis was confirmed to have a positive effect on disease free survival Complete surgical resection is the mainstay of treatment. A worldwide registry is urgently required to collect data to standardize treatment and to obtain reliable data on prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

et al. 2018

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“…Primary vaginal adenosarcoma is extremely rare. Only four cases have been reported in English literature 3–6 . Patients’ age ranged from 42 to 56 years.…”

Section: Discussionmentioning

confidence: 99%

Vaginal adenosarcoma arising from refractory endometriosis: A case report

Han¹,

Leng²,

Guo

et al. 2010

Aust NZ J Obst Gynaeco

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“…Follow-up was available for one of the two patients; she remained disease-free at 2 years. Several reports of vaginal adenosarcoma associated with endometriosis have also been reported, most recently reviewed by Toyoshima [15]. …”

Section: Commentmentioning

confidence: 99%

Extragenital adenosarcoma: A case report, review of the literature, and management discussion

Huang¹,

Arend²,

Sakaris³

et al. 2009

Gynecologic Oncology

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Background Müllerian adenosarcoma is a rare mixed epithelial-mesenchymal tumor. An extragenital site of origin and sarcomatous overgrowth are associated with aggressive clinical behavior. Case We present a rare case of extragenital adenosarcoma with sarcomatous overgrowth and coexistent endometrioisis. She was treated with initial cytoreductive surgery and chemotherapy. She underwent a second surgery for management of a high-grade bowel obstruction, due to pathologically confirmed recurrent intraperitoneal adenosarcoma. A complete clinical response was achieved with liposomal doxorubicin, and the patient remains disease-free eighteen months after completion of chemotherapy. Conclusion Liposomal doxorubicin appears to be an active agent for the treatment of adenosarcoma with sarcomatous overgrowth. In addition, we conclude from our review of all reported cases of extragenital adenosarcoma that concurrent endometriosis may represent a favorable prognostic factor.

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Primary vaginal adenosarcoma with sarcomatous overgrowth

Cited by 15 publications

References 10 publications

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

Vaginal adenosarcoma arising from refractory endometriosis: A case report

Extragenital adenosarcoma: A case report, review of the literature, and management discussion

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