Primary Vaginal Mucinous Adenocarcinoma of Intestinal Type, Associated With Intestinal Metaplasia of Skene Ducts in a Diethylstilbestrol-Exposed Woman

Tatsumi, Kanayo; Schlappe, Brooke A.; Everett, Elise; Gibson, Pamela Church; Mount, Sharon L.

doi:10.1309/ajcpvz0qnluo7ofe

Cited by 17 publications

(26 citation statements)

References 18 publications

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“…In support of this, one reported case of gynaecological primary mucinous adenocarcinoma of intestinal type was associated with Skene ducts showing intestinal metaplasia. 11 Finally, it is theoretically possible that the adenocarcinoma of case 2 originated from the overlying Paget's disease, but this potential source could not explain the carcinoma of case 1.…”

Section: Discussionmentioning

confidence: 99%

“…However, the potential for this specific variant of peri‐anal adenocarcinoma to develop is supported by reports of adenocarcinoma of intestinal type developing in the nearby female genital tract, e.g. vagina . As with its gynaecological counterpart, the structures/cells from which primary peri‐anal adenocarcinoma of intestinal type arises are uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…vagina. 11,12 As with its gynaecological counterpart, the structures/cells from which primary peri-anal adenocarcinoma of intestinal type arises are uncertain. It is possible that peri-anal adenocarcinoma arises from a non-fistulating duplication cyst or from smaller congenital rests (so-called cloacogenic remnants).…”

Section: Discussionmentioning

confidence: 99%

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Primary peri‐anal adenocarcinoma of intestinal type – a new proposed entity

Gill

Wong

2018

Histopathology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary peri‐anal adenocarcinoma of intestinal type – a new proposed entity

Gill

Wong

2018

Histopathology

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“…and pulmonary metastases. 7,8 The first type (DES-associated) occurs in younger women and the last in postmenopausal women. 1,2,4 In this case, there was no report of patient exposure to DES.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the reported cases are of adenocarcinoma, mainly of the intestinal type, that may or may not be associated with in utero DES use. 7,8 The first type (DES-associated) occurs in younger women and the last in postmenopausal women. 9 Rajaram et al considered that non-DESassociated cancers are currently described more frequently due to decreasing DES use during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Poorly differentiated vaginal adenocarcinoma with aggressive behavior—Pap smear findings

Eleutério

Freitas²,

Oliveira

et al. 2017

Diagnostic Cytopathology

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Vaginal carcinoma is a rare condition. In this report, we describe a case of a poorly differentiated aggressive adenocarcinoma in a woman with a three month history of vaginal bleeding and a negative Pap smear done six months prior to her consultation. Specular examination showed a normal cervix, but there was a bleeding ulcer (2 cm in diameter) in the upper third of the vagina. Cytology revealed poorly differentiated atypical cells, and the biopsy established a diagnosis of vaginal adenocarcinoma with little differentiation. Within two months, the patient died without diagnosis of a primary tumor site other than the vagina.

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The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

Mallozzi¹,

Bordi²,

Garo³

et al. 2016

Birth Defects Research Pt C

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There is a widespread exposure of general population, including pregnant women and developing fetuses, to the endocrine disrupting chemicals (EDCs). These chemicals have been reported to be present in urine, blood serum, breast milk, and amniotic fluid. Endocrine disruptions induced by environmental toxicants have placed a heavy burden on society, since environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life-a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly-regulated and precisely-timed molecular, biochemical, and cellular events. Humans may encounter EDCs daily and during all stages of life, from conception and fetal development through adulthood and senescence. Nevertheless, prenatal and early postnatal windows are the most critical for proper development, due to rapid changes in system growth. Although there are still gaps in our knowledge, currently available data support the urgent need for health and environmental policies aimed at protecting the public and, in particular, the developing fetus and women of reproductive age. Birth Defects Research (Part C) 108:224-242, 2016. © 2016 Wiley Periodicals, Inc.

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Primary Vaginal Mucinous Adenocarcinoma of Intestinal Type, Associated With Intestinal Metaplasia of Skene Ducts in a Diethylstilbestrol-Exposed Woman

Abstract: Recognition of this rare entity is important, particularly to avoid the pitfall of misdiagnosing metastatic disease.

Cited by 17 publications

References 18 publications

Primary peri‐anal adenocarcinoma of intestinal type – a new proposed entity

Primary peri‐anal adenocarcinoma of intestinal type – a new proposed entity

Poorly differentiated vaginal adenocarcinoma with aggressive behavior—Pap smear findings

The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

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