Primary Well Differentiated Liposarcoma: An Unusual Tumor in the Breast

Abstract

A 43-year-old woman, presented with a tender mobile lump in the lower inner quadrant of the left breast. On examination, there was no local lymphadenopathy. Mammography showed a 20 mm, dense, well circumscribed lesion suggesting a fibroadenoma (Fig. 1). The lump was excised and no axillary dissection was made.Grossly, the specimen excised measured 35 · 25 · 15 mm, it was occupied by a well circumscribed, yellow, firm mass. No areas of necrosis were identified.At histological examination (Fig. 2), the tumor had well-defined margins. It was composed of an adipocytic proliferation presenting a variation in cell size with focal nuclear atypia and hyperchromasia. Scattered atypical, hyperchromatic stromal cells were noted in a fibrillary, collageneous stroma. Occasionally, a varying number of monovacuolated or multivacuolated lipoblasts were recognized. An arborizing Figure 2. Associated osteoclast-like giant cells (arrows).Figure 3. Tumor cells were synaptophysin positive whereas the osteoclast-link giant cells were negative (arrow).

Breast liposarcoma

“…Dans tous les types, des lipoblastes sont toujours présents, uniou multivacuolés avec des noyaux crantés (7,8).…”

Primary Breast Liposarcoma

“…There is no consensus about imaging presentation of breast sarcomas, for example Berg et al [1], Lamia Charfi et al [7], describes that mammographically, these tumors often present as a well limited, round, oval or polycyclic opacity. So the mammographic impression in some cases may be of a benign fibroadenoma.…”

Mesenchymal tumours of the breast and their mimics: a review with approach to diagnosis

“…102 The reported age is 19-76 years. [96][97][98][99][100][101]103 Features on MRI that raise suspicion for atypical lipomatous tumour include thickened or nodular septa, prominent foci of high T2 signal, non-fatty areas and prominent areas of contrast enhancement. 104 Pathology Atypical lipomatous tumour is typically composed of mature fat with irregular fibrous bands and scattered pleomorphic cells with a variably prominent loose collagenous matrix.…”

“…[96][97][98][99][100][101] Atypical lipomatous tumour can occur in mammary parenchyma, or it may also arise as an intramuscular mass within the pectoralis muscle, mimicking a primary breast tumour. 102 The reported age is 19-76 years.…”