Primary yolk sac (endodermal sinus) tumor of the prostate: Case report and review of the literature

Schriber, Jeff; Flax, Stanley; Trudeau, Maureen; Cook, Gerald T.; Weizel, H. A. E.; Katz, Alan J.; Keating, Armand

doi:10.1002/pros.2990170207

Cited by 14 publications

(12 citation statements)

References 16 publications

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“…The first report of a positive response to cisplatinbased therapy was described in 1990 in a patient who received cisplatin, vinblastine, dactinomycin and bleomycin. Although the patient expired from postsurgical complications, autopsy revealed no evidence of tumor [3] . Two further cases demonstrated cisplatin-based therapy as successful [4,5] .…”

Section: Discussionmentioning

confidence: 99%

“…The patient relapsed 2 months following treatment and expired shortly thereafter. Another patient expired from relapse within 1 year of receiving two rounds of a cisplat- [2] 1988 CIS, BLEO yes died after 10 months Schriber [3] 1990 CIS, BLEO, VCR, DACT yes died after 4 months Tay [4] 1995 CIS, ETOP, BLEO* yes alive, free of disease Namiki [5] 1999 CIS, VLB, BLEO no alive, with disease Han [12] 2003 in, vinblastine and bleomycin, in addition to two rounds of adriablastin, etoposide, dactinomycin and methotrexate [2] . The first report of a positive response to cisplatinbased therapy was described in 1990 in a patient who received cisplatin, vinblastine, dactinomycin and bleomycin.…”

Section: Discussionmentioning

confidence: 99%

“…However, subsequent cases revealed evidence that primary EST of the prostate was amenable to chemotherapeutic treatment, especially cisplatin-based therapy [2][3][4][5] . Moreover, there have been three previous cases of metastatic testicular tumors to the prostate, including one incidence of EST [6] .…”

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confidence: 99%

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Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Furr

Mellis²,

Slobodov³

2015

Urol Int

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Endodermal sinus (yolk sac) tumors (ESTs) are rare neoplasms that most commonly arise in the ovaries or testis. Only six cases of prostatic ESTs have been reported in the literature. We report a case of prostatic EST, the first case in which the patient had a history of previous testis cancer. Treatment included cisplatin-based chemotherapy and radical prostatectomy. Previous cases of primary ESTs and use of cisplatin-based therapy as well as metastatic tumors to the prostate are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Furr

Mellis²,

Slobodov³

2015

Urol Int

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“…Thirteen cases of extragonadal GCT of the prostate have been reported. The diagnosis of a primary GCT is made in the absence of concomitant GCT from usual sites of involvement (testis or mediastinum).The reported cases of prostatic GCT have occurred mostly in young adults with a mean age of 40.8 years (range 24–51 years); three patients had Klinefelter’s syndrome 211–223 . The clinical presentation includes haematuria, dysuria, obstructive symptoms, haemospermia, and pelvic pain.…”

Section: Germ Cell Tumour (Gct)mentioning

confidence: 99%

Non‐epithelial neoplasms of the prostate

et al. 2011

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Non-epithelial prostatic neoplasms are infrequent and cover a broad array of entities that include both benign and highly aggressive tumours. Because they are very infrequent, there is often limited understanding of them, and the recognition of these entities, when encountered, may pose a diagnostic challenge, owing to histological overlap between them or their rarity. Most lesions in this category are mesenchymal in origin, such as prostatic stromal tumours arising from specialized prostatic stroma, smooth muscle tumours, both benign and malignant, and solitary fibrous tumours. Less commonly occurring tumours include neural, germ cell and melanocytic tumours that may be derived from cells not normally present in the prostate. Some tumours have well-established extraprostatic counterparts and, when encountered, are more commonly extraprostatic/secondary in origin; these include gastrointestinal stromal tumours and most haematopoietic tumours. The majority of tumours are characterized by a spindle cell pattern with significant overlap in morphological features. In this setting, appropriate use of immunohistochemistry and molecular studies are often necessary for accurate diagnosis, prognosis, or prediction for therapy. This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis.

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“…Additionally the possibility of a metastatic lesion from a testicular primary should be eliminated using the criteria of Abell et al As for treatment, it appears that patients who received preoperative combination chemotherapy 222,224,227 did better than patients who received their chemotherapy postoperatively. [219][220][221] This again emphasizes the importance of making the correct diagnosis on biopsy. The theories postulated for the origin of primary GCT of the prostate are similar to those put forward to explain the origin of extragonadal GCT in general.…”

mentioning

confidence: 91%

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

Shabaik

2003

Critical Reviews in Clinical Laboratory Sciences

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Many significant benign and malignant nonepithelial tumors and stromal tumor-like lesions arise in the prostate gland. Although such lesions are rare, their recognition by the pathologist is essential because their treatment and prognosis are quite variable. In this review, lesions of the specialized prostatic stroma, that is, lesions that can be seen in the stroma of the prostate but not in that of other organs, except for the phyllodes type of lesions, are discussed. Benign and malignant lesions of the soft tissues that occur in the stroma of other organs and are seen with some frequency in the prostate are also discussed. Few of the rarer soft tissue lesions are mentioned. Lesions and tumors with melanocytic differentiation, hematopoietic derivation, and germ cell tumors are described. It is hoped that this review will serve as a useful reference when encountering some of these lesions, all of which are referenced to their original and subsequent reports. Some non-English language references are also cited to reflect the international recognition of these lesions or to give credit to the author who first described the entity.

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Primary yolk sac (endodermal sinus) tumor of the prostate: Case report and review of the literature

Cited by 14 publications

References 16 publications

Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature

Non‐epithelial neoplasms of the prostate

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

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