Primary Yolk Sac Tumor Arising in the Pancreas with Hepatic Metastasis: a Case Report

Abstract

Extragonadal yolk sac tumor (YST) is a relatively rare entity. We describe here the case of an extragonadal YST that occurred in the pancreas with hepatic metastasis in an adult woman. The contrast enhanced CT images of the abdomen revealed a heterogeneous, solitary mass occupying the pancreatic neck and body with slightly inhomogeneous contrast enhancement. Two low-density lesions in the liver were also displayed on the CT images. The patient underwent surgery and the diagnosis of YST was pathologically verified.

Primary yolk sac tumor of omentum: A case report

“…Mass of ovary was one of metastatic seeding nodules as like those disseminated in abdominal and pelvic cavity. Generally, gonadal YST is a disease with a peak incidence at 20 years [5], however, the ages of in w primary YST of omentum omen previous reported were is 37, 44, 45, and 46 years implicating a rather older women's disease [2,4,6]. However, primary YST of omentum in our report showed a general young age of gonadal YSTs.…”

“…Our patient also showed complete response with 6 cycyles of BEP combination chemotherapy. Although long term outcome of omental YST is not well known, all the 5 patients with primary YST of omentum reported showed a favorable outcome [2,4,6]. In this report, the patient showed no evidence of disease on physical examination and serum a-fetoprotein level and imaging studies for 2 years without any menstrual abnormality.…”

“…In previous report, the average age of the 4 women with a primary YST of omentum was 43 years and there was no need to 'fertility-saving surgery'. Actually total hysterectomy was performed in all the 4 women with primary YST of omentum [2,4,6]. However, in this report, we performed fertility saving surgery consisting of removal of the pelvic tumor, pelvic lymphadenectomy, omentectomy and resection of abdominal metastases with preservation of the uterus and both ovaries.…”

“…Although the child bearing outcome is not confi rmed yet, this is the fi rst report that fertility saving surgery was performed in primary YST of omentum. Primary YST of omentum responds well to combination chemotherapy [2,4,6]. A regimen of BEP has been a major advance in the therapy of advanced and localized germ cell tumors [3].…”

“…Although most of YST occurs in the ovaries, 10 to 15% of YST may arise in extragonadal sites, such as the mediastinum, the pineal region, and sacrococcygeal region and the female reproductive tract [5]. Among them primary YST of omentum is extremely rare and only 5 cases are reported currently, and the pathogenesis and the clinical characteristics are unknown [1,2,[4][5][6]. We report a case of primary YST of the omentum in 27-year-old women and discuss the clinical and histologic features in conjunction with a review of the literature.…”