Printed Organic Transistor-based Biosensors for Non-invasive Sweat Analysis

Nagamine, Kuniaki; Nomura, Ayako; Ichimura, Yusuke; Izawa, Ryota; Sasaki, Sadao; Furusawa, Hiroyuki; Matsui, Hiroyuki; Tokito, Shizuo

doi:10.2116/analsci.19r007

Cited by 28 publications

(17 citation statements)

References 140 publications

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“…The main advantage offered by the extended gated configuration is the fact that the sensing part of the device is the only one exposed to the environment in which the measurement is performed, and this ensures better stability and reproducibility. 67 In spite of the advantages offered by the latter configuration, in our literature survey we have found very few significant examples of extended gated EG-CNTFETs, the only remarkable one being the one reported by Yamamoto et al 57 It is worth mentioning that some authors, for example, Shibani et al, in their work about cortisol detection, 68 use "EG-FET" as an acronym for extended gated FET, as there is no universal agreement in the field on how to refer to the specific configurations.…”

Section: A Eg-fet Configurationsmentioning

confidence: 99%

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Shkodra

Petrelli

Angeli

et al. 2021

Applied Physics Reviews

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Nowadays, there is a high demand for sensitive and selective real-time analytical methods suitable for a wide range of applications, from personalized telemedicine, drug discovery, food safety, and quality control, to defense, security, as well as environmental monitoring. Biosensors are analytical devices able to detect bio-chemical analytes (e.g., neurotransmitters, cancer biomarkers, bio-molecules, and ions), through the combination of a bio-recognition element and a bio-transduction device. The use of customized bio-recognition elements such as enzymes, antibodies, aptamers, and ion-selective membranes facilitates achieving high selectivity. Among the different bio-transduction devices currently available, electrolyte-gated field-effect transistors, in which the dielectric is represented by an ionic liquid buffer solution containing the targeted analyte, are gaining increasing attention. Indeed, these biotransduction devices are characterized by superior electronic properties and intrinsic signal amplification that allow the detection of a wide rangeofbiomolecules with high sensitivity (down to pM concentration). A promising semiconducting material for bio-transduction devices is represented by carbon nanotubes, due to their unique electrical properties, nanosize, bio-compatibility, and their simple low-cost processability. This work provides acomprehensive and critical review of electrolyte-gated carbon nanotube field-effect transistor-based biosensors. First, an introduction to these bio-sensing devices is given. Next, the device configurations and operating principles are presented, and the most used materials and processes are reviewed with a particular focus on carbon nanotubes as the active material. Subsequently, different functionalization strategies reported in the literature, based on enzymes, antibodies, aptamers, and ion-selective membranes, are analyzed critically. Finally, present issues and challenges faced in the area are investigated,theconclusions are drawn, and a perspective outlook over the field of bio-sensing technologies, in general, is provided.

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Section: A Eg-fet Configurationsmentioning

confidence: 99%

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Shkodra

Petrelli

Angeli

et al. 2021

Applied Physics Reviews

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“…Others include colorimetric sensing that utilizes electrochemical colorimetric indicators, [19] and transistor-based sensing that includes enzyme-functionalized electrodes in transistor configuration. [20][21][22] Among these technologies, organic transistors have emerged as a promising platform for wearable biosensors as they possess a number of advantages. [23][24][25][26] For example, they can be fabricated on wearable substrates, can amplify weak signals obtained from biological events and can be functionalized with a variety of molecular recognition materials for selective detection.…”

Section: Doi: 101002/mabi202000144mentioning

confidence: 99%

“…Others include colorimetric sensing that utilizes electrochemical colorimetric indicators, [ 19 ] and transistor‐based sensing that includes enzyme‐functionalized electrodes in transistor configuration. [ 20–22 ]…”

Section: Figurementioning

confidence: 99%

A Flexible 3D Organic Preamplifier for a Lactate Sensor

Baek

Kwon

Mano

et al. 2020

Macromolecular Bioscience

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Organic transistors are promising platforms for wearable biosensors. However, the strategies to improve signal amplification have yet to be determined, particularly regarding biosensors that generate very weak signals. In this study, an organic voltage amplifier is presented for a lactate sensor on flexible plastic foil. The preamplifier is based on a 3D complementary inverter, which is achieved by vertically stacking complementary transistors with a shared gate between them. The shared gate is extended and functionalized with a lactate oxidase enzyme to detect lactate. The sensing device successfully detects the lactate concentration in the human sweat range (20–60 mm) with high sensitivity (6.82 mV mm−1) due to high gain of its amplification. The 3D integration process is cost‐effective as it is solution‐processable and doubles the number of transistors per unit area. The device presented in this study would pave the way for the development of high‐gain noninvasive sweat lactate sensors that can be wearable.

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“…As mentioned previously, sweat has been an emerging source of information in both forensics and biometrics. Many studies have been done for the advancement of various methodologies for different compounds found in sweat [ 84 , 85 , 86 , 87 , 88 ]. Further descriptions of some of the recent methodologies that have been developed for sweat analysis can be seen in Table 1 below.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Noninvasive Biosensors for Forensics, Biometrics, and Cybersecurity

McGoldrick

Halámek

2020

Sensors

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Recently, biosensors have been used in an increasing number of different fields and disciplines due to their wide applicability, reproducibility, and selectivity. Three large disciplines in which this has become relevant has been the forensic, biometric, and cybersecurity fields. The call for novel noninvasive biosensors for these three applications has been a focus of research in these fields. Recent advances in these three areas has relied on the use of biosensors based on primarily colorimetric assays based on bioaffinity interactions utilizing enzymatic assays. In forensics, the use of different bodily fluids for metabolite analysis provides an alternative to the use of DNA to avoid the backlog that is currently the main issue with DNA analysis by providing worthwhile information about the originator. In biometrics, the use of sweat-based systems for user authentication has been developed as a proof-of-concept design utilizing the levels of different metabolites found in sweat. Lastly, biosensor assays have been developed as a proof-of-concept for combination with cybersecurity, primarily cryptography, for the encryption and protection of data and messages.

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Printed Organic Transistor-based Biosensors for Non-invasive Sweat Analysis

Cited by 28 publications

References 140 publications

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

A Flexible 3D Organic Preamplifier for a Lactate Sensor

Recent Advances in Noninvasive Biosensors for Forensics, Biometrics, and Cybersecurity

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