Prior treated tuberculosis and mortality risk in lung cancer

Abstract

BackgroundLung cancer is one of the leading causes of cancer death worldwide, and tuberculosis (TB) is a common pre-existing disease. However, there is scarce literature studying the mortality risk in patients with prior TB and subsequent lung cancer.MethodsWe recruited lung cancer patients from the Taiwan Cancer Registry from 2011 to 2015 and classified them into two groups according to presence or absence of prior TB. We then matched them in a ratio of 1:4 using the exact matching approach. The mortality risk within 3 years after diagnosis of lung cancer was analyzed and compared between these two groups.ResultsDuring the study period, 43,472 patients with lung cancer were recruited, and of these, 1,211 (2.79%) patients had prior TB. After matching, this cohort included 5,935 patients with lung cancer in two groups: patients with prior TB before lung cancer (n = 1,187) and those without (n = 4,748). After controlling for demographic factors and comorbidities, the patients with prior TB had increased adjusted hazard ratios of 1.13 (95% CI: 1.04–1.23) and 1.11 (1.02–1.21) for all-cause and cancer-specific 3-year mortality, respectively, compared to the lung cancer patients without prior TB. Duration between TB and lung cancer (<1 year vs. 1–3 years vs. >3 years) had no differences for mortality risk.ConclusionIn the present study, 2.79% patients with lung cancer had prior TB, which was associated with higher 3-year mortality after they developed lung cancer. The mortality risk with prior TB did not decrease even if >3 years passed before diagnosis of lung cancer.

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

“…M.tb has been reported to be a risk factor for lung cancer [ 68 , 69 ]. Pulmonary tuberculosis significantly promotes lung cancer metastasis [ 70 ] and increases mortality in lung cancer patients [ 71 ]. The PD-1/PD-L1 pathway was found to be involved in M.tb infection, which suppress the host Th1 immune response and eventually promotes lung cancer development [ 72 ].…”

Nhận Xét Một Số Đặc Điểm Bệnh Lý Của Bệnh Nhân Có Tổn Thương Dạng U Đơn Độc Ngoại Vi Phổi Căn Nguyên Do Lao

“…1 Đồng quan điểm này, Ming Liao K. và cs (2023) cho biết nguy cơ này là 1,13 lần. 3 Trong nghiên cứu chúng tôi, tỷ lệ BN ung thư phổi có tiền sử mắc bệnh lao phổi là 2,0%. Phân tích số liệu cho thấy, ở BN có tiền sử mắc bệnh lao, khi phát hiện có tổn thương dạng u ở phổi, khả năng khối u đó có bản chất là u lao cao hơn ung thư, sự khác biệt có ý nghĩa thống kê (p < 0,05).…”