Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer

Park, Ju-Hyung; Kim, Jin‐Kyung

doi:10.1016/j.phymed.2018.03.033

Cited by 39 publications

(34 citation statements)

References 28 publications

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“…This may provide the basis for the varied ethnomedicinal uses of TBG in Nigerian South-western Traditional medicine where it is called "all-purpose plant" in folklore. In particular, sesquiterpenoids and triterpenoids 16 are of scientific interest as potential sources of nature-derived angiogenic modulators [26]. The characterization of triterpenoids from the seeds of TGB [12] and our current isolation and detection of an anti-angiogenic triterpenoids in this plant is therefore consistent with previous literature reports.…”

Section: Ut: Untreated Cam'ssupporting

confidence: 85%

Anti-angiogenic activities of the leaves of Tapinanthus bangwensis (Engl. and K. Krause) Danser Loranthaceae growing on three host trees in south-western Nigeria

Adeagbo

et al. 2019

Preprint

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The control of angiogenic process is of immense importance to the overall health of mankind to avert out-of-control complications such as tumours and cancers. Tapinanthus bangwensis (TBG) is a semi-parasitic plant with multipurpose uses in Nigerian ethno-medicine among which is its anti-infective properties as well as the anti-tumor and restoration of damaged tissues. Despite the wide and varied uses of TBG, the anti-angiogenic investigation of the plant on different host trees is lacking while the documentation and scientific validation of indigenous knowledge on plants' use is urgent. The present work focuses on the anti-angiogenic activities of the crude extracts and partitioned fractions of the leaves of Tapinanthus bangwensis (TBG) using the Chick chorio allantoic membrane (CAM) model. The plant was collected from three different host trees namely Albizia lebbeck (AL), Stereospermum kunthianum (SK) and Tabebuia rosea (TR). The methanolic crude extracts and solvent-partitioned fractions of TBG-SK samples were assessed for their anti-angiogenic activities using the chick chorio allantoic membrane (CAM) in ovo and in vitro assay methods respectively. Purification and isolation of major compound(s) in the chloroform fraction of TBG extract obtained from Stereospermum kunthianum host tree (TBG-SK) was carried out using chromatographic and spectroscopic methods (NMR, MS).The crude methanolic extract of TBG-SK was most potent (100% activity) in the CAM in ovo assay while the chloroform fraction produced a significantly (p<0.05) highest average reduction in blood vessels with resultant formation of large avascular zones on CAM following an in vitro CAM assay. The anti-angiogenic chloroform fraction revealed the presence of a UV-active triterpenoid moiety. Findings from this work, has provided some justification for the folkloric use of TBG and thus forms a potential basis for drug discovery for wide-ranging disease states.

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Section: Ut: Untreated Cam'ssupporting

confidence: 85%

Anti-angiogenic activities of the leaves of Tapinanthus bangwensis (Engl. and K. Krause) Danser Loranthaceae growing on three host trees in south-western Nigeria

Adeagbo

et al. 2019

Preprint

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“…Several studies have documented the anticancer activity of pristimerin in vitro and in vivo. [8][9][10][11][12][13] For example, pristimerin inhibits cell proliferation and induces apoptosis through suppression of proteasome activity and NF-κB pathway signaling. [22,23] In addition, pristimerin induced ROS generation and subsequent JNK activation during cell death.…”

Section: Pristimerin Triggers Apoptosis and Autophagy By Ros/jnk Pathmentioning

confidence: 99%

“…[6,7] Recently, pristimerin has been reported to exert promising therapeutic effect on several malignancies. [8][9][10][11][12][13] Although pristimerin exhibits a variety of anticancer activities, its effects and mechanisms on CML have not been completely explored.…”

Section: Introductionmentioning

confidence: 99%

Pristimerin Induces Autophagy‐Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway

Liu

Ren

et al. 2019

Chemistry & Biodiversity

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Chronic myeloid leukemia (CML) is a lethal malignancy, and the progress toward long‐term survival has stagnated in recent decades. Pristimerin, a quinone methide triterpenoid isolated from the Celastraceae and Hippocrateaceae families, is well‐known to exert potential anticancer activities. In this study, we investigated the effects and the mechanisms of action on CML. We found that pristimerin inhibited cell proliferation of K562 CML cells by causing G1 phase arrest. Furthermore, we demonstrated that pristimerin triggered autophagy and apoptosis. Intriguingly, pristimerin‐induced cell death was restored by an autophagy inhibitor, suggesting that autophagy is cross‐linked with pristimerin‐induced apoptosis. Further studies revealed that pristimerin could produce excessive reactive oxygen species (ROS), which then induce JNK activation. These findings provide clear evidence that pristimerin might be clinical benefit to patients with CML.

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“…In addition, Yousef and colleagues demonstrated pristimerin anticancer activity on colon tumor cells associated to NF-κB signaling inhibition during the carcinogenic process [338,339]. Corroborating, this triterpenoid has also been shown to attenuated colitis-associated colon cancer by modulating NF-κB positive cells, as well as AKT/FOXO3a signaling pathway [340]. The transcription factor FOXO3 represents important target for cellular homeostasis, since it was able to regulate apoptosis, proliferation, cell cycle progression, and consequently tumorigenesis [341,342].…”

Section: Pristimerinmentioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

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Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

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Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer

Cited by 39 publications

References 28 publications

Anti-angiogenic activities of the leaves of Tapinanthus bangwensis (Engl. and K. Krause) Danser Loranthaceae growing on three host trees in south-western Nigeria

Anti-angiogenic activities of the leaves of Tapinanthus bangwensis (Engl. and K. Krause) Danser Loranthaceae growing on three host trees in south-western Nigeria

Pristimerin Induces Autophagy‐Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

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