Pro-apoptotic effects of 1′-acetoxychavicol acetate in human breast carcinoma cells

The effect of sea anemone (H. magnifica) venom on two human breast cancer lines: death by apoptosis

“…Cell treatment with H. magnifica venom induced accumulation of a sub-G 1 population with a concomitant decrease in the G1 phase, supporting that the induction of apoptosis was occurring. Apoptosis can play a crucial defense role against the propagation of cancer and the induction of this process is one mechanism by which chemotherapeutic agents can kill cancer cells (Campbell et al 2007). There are at least two broad pathways that lead to apoptosis, the death receptor pathway (extrinsic) and the mitochondrial pathway (intrinsic).…”

Antibacterial activity of Thai herbal extracts on acne involved microorganism

“…It has been reported that 1′-ACA possesses various biological activities, such as antitumor (Itokawa et al, 1987;Kondo et al, 1993;Moffatt et al, 2000;Zheng et al, 2002;Ito et al, 2005;Azuma et al, 2006;Campbell et al, 2007), anti-inflammation (Nakamura et al, 1998;Morikawa et al, 2005), antifungal (Janssen & Scheffer, 1985), antiviral (Ye & Li, 2006), antioxidative (Kubota et al, 2001), and xanthine oxidase inhibitory activity (Noro et al, 1988). Although it has been reported that the ethanol extract of A. galanga exhibits antibacterial activity against S. aureus (Oonmetta-aree et al, 2006), the antibacterial activity of 1′-ACA has not yet been reported.…”

Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells

“…Many investigators reported that naturally occurring chavicol acetate, ACA induced apoptosis of several tumor cells such as Ehrlich ascites tumor cells [33], human myeloid leukemic cells [14], myeloma cells [34] and human breast carcinoma cells [35], but it has been barely studied on pro-apoptotic activity in normal cells or immune cells. Another chavicol derivative, HCA possesses 1′-hydroxypropenyl group on the benzene ring, which is distinguished from 1′-acetoxypropenyl group of ACA, but remains to be characterized on the functions.…”