Pro-ejaculatory effect of the aqueous crude extract of cihuapatli (Montanoa tomentosa) in spinal male rats

Carro‐Juárez, Miguel; Lobatón, Isaac; O, Benitez; Espíritu, Alejandra

doi:10.1016/j.jep.2005.12.011

Cited by 32 publications

(32 citation statements)

References 17 publications

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“…This model permits the recording and visualization of the rhythmic motor pattern of ejaculation accompanied by complex pelvic activity that includes phasic and strong penile erections, as well as penile movements followed by the potent expulsion of urethral contents. The rhythmic motor pattern of ejaculation registered in this experimental model is elicited by urethral and penile stimulations and can additionally be induced by systemic administration of several drugs including medicinal plant extracts [3,19-21]. Growing evidence shows that dopamine is a neurotransmitter playing a central role in the control of ejaculation [31,32].…”

Section: Introductionmentioning

confidence: 99%

Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats

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Wankeu-Nya

et al. 2013

BMC Complement Altern Med

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BackgroundMondia whitei and Guibourtia tessmannii are used in Cameroon traditional medicine as aphrodisiacs. The present study was undertaken to evaluate the pro-ejaculatory effects of the aqueous and organic solvent extracts of these plants in spinal male rats.MethodsIn spinal cord transected and urethane-anesthetized rats, two electrodes where inserted into the bulbospongiosus muscles and the ejaculatory motor pattern was recorded on a polygraph after urethral and penile stimulations, intravenous injection of saline (0.1 ml/100 g), dopamine (0.1 μM/kg), aqueous and organic solvent plant extracts (20 mg/kg).ResultsIn all spinal rats, urethral and penile stimulations always induced the ejaculatory motor pattern. Aqueous or hexane extract of Mondia whitei (20 mg/kg) prevented the expression of the ejaculatory motor pattern. The pro-ejaculatory effects of dopamine (0.1 μM/kg) were not abolished in spinal rats pre-treated with Mondia whitei extracts. Aqueous and methanolic stem bark extracts of Guibourtia tessmannii (20 mg/kg) induced fictive ejaculation characterized by rhythmic contractions of the bulbospongiosus muscles followed sometimes with expulsion of seminal plugs. In rats pre-treated with haloperidol (0.26 μM/kg), no ejaculatory motor pattern was recorded after intravenous injection of Guibourtia tessmannii extracts (20 mg/kg).ConclusionThese results show that Mondia whitei possesses preventive effects on the expression of fictive ejaculation in spinal male rats, which is not mediated through dopaminergic pathway; on the contrary, the pro-ejaculatory activities of Guibourtia tessmannii require the integrity of dopaminergic system to exert its effects. The present findings further justify the ethno-medicinal claims of Mondia whitei and Guibourtia tessmannii.

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Section: Introductionmentioning

confidence: 99%

Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats

Watcho

Defo

Wankeu-Nya

et al. 2013

BMC Complement Altern Med

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“…The data showed that the extract acts directly at the spinal system in charge of the expression of the ejaculatory motor patterns and suggest that the aqueous crude extract exerts its aphrodisiacs properties by increasing sexual potency acting as an oxytocic agent. [60]…”

Section: Herbal Aphrodisiacsmentioning

confidence: 99%

Exploring scientifically proven herbal aphrodisiacs

Kotta¹,

Ansari²,

Ali³

2013

Phcog Rev

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Procreation was an important moral and religious issue and aphrodisiacs were sought to ensure both male and female potency. Sexual dysfunction is an inability to achieve a normal sexual intercourse, including premature ejaculation, retrograded, retarded or inhibited ejaculation, erectile dysfunction, arousal difficulties (reduced libido), compulsive sexual behavior, orgasmic disorder, and failure of detumescence. The introduction of the first pharmacologically approved remedy for impotence, Viagra (sildenafil) in 1990s caused a wave of public attention, propelled in part by heavy advertising. The search for such substances dates back millennia. An aphrodisiac is an agent (food or drug) that arouses sexual desire. The hunt for natural supplement from medicinal plants is being intensified mainly because of its fewer side effects. In this review, we have mentioned the pharmacologically tested (either in man or animal or in both) aphrodisiac plants, which have claimed for its uses.

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“…An aphrodisiac can be described as any substances that were used to treat a sexual disorder or to enhance sexual behaviour and satisfaction in humans and animals. It acts primarily by altering the level of specific neurotransmitters or specific sex hormone into the body, i. e alteration in testosterone level [23]. Several in vivo and in vitro models have been established for the determination of aphrodisiac activity [22].…”

Section: Introductionmentioning

confidence: 99%

Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

Jayusman

Mohamed

Thu

et al. 2017

Int J Pharm Pharm Sci

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Objective: This systematic review was conducted to summarize and evaluate the effect of Eurycoma longifolia (EL) on sexual behavior in the sexually dysfunctional male.Methods: Ovid Medline, Wiley Online Library, Scopus, BioMed Central, Hindawi and Google Scholar databases were searched for relevant studies published from 1995 to 2016 and search was limited to relevant studies published in English. Studies assessing aphrodisiac properties of EL on male sexual behavior in sexually dysfunctional animal models or human were included. Results:Among the 155 studies identified in the literature search, a total of 6 eligible articles (5 animal studies and one human study) were selected and reviewed. All studies reported positive aphrodisiac activities and supported the use of the plant as an aphrodisiac. Conclusion:This systematic review highlighted the effect of EL extract as an aphrodisiac agent to improve sexual behavior in the sexually dysfunctional male. Further studies are required to determine the specific mechanisms of action and identification of the bioactive components of EL responsible for its potential efficacy.

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Pro-ejaculatory effect of the aqueous crude extract of cihuapatli (Montanoa tomentosa) in spinal male rats

Cited by 32 publications

References 17 publications

Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats

Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats

Exploring scientifically proven herbal aphrodisiacs

Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

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