Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia

Mayer, Andrew R.; Hanlon, Faith M.; Dodd, Andrew B.; Yeo, Ronald A.; Haaland, Kathleen Y.; Ling, Josef M.; Ryman, Sephira G.

doi:10.1503/jpn.150097

Cited by 18 publications

(31 citation statements)

References 64 publications

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“…A full description of the proactive response inhibition task has previously been reported (Mayer et al, ). Briefly, a multisensory cue (audiovisual; 300 ms duration) was presented at the beginning of each block (Figure a), determining the modality for focused attention (“HEAR” = attend‐auditory; “LOOK” = attend‐visual) or for the planned inhibition of upcoming motor responses (“NONE” = proactive response inhibition).…”

Section: Methodsmentioning

confidence: 99%

“…In the cognitive neuroscience literature, deficits in response inhibition are measured in response to either reactive (i.e., inhibiting a prepotent motor responses after the stimulus occurs) or proactive (i.e., inhibiting responses in a planned and purposeful manner) demands (Criaud & Boulinguez, ). Proactive inhibition typically results in a negative or suppressed BOLD response in healthy motor circuitry in contrast to hyperactivation in psychopathology (Li, Lai, & Chen, ; Mayer et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Independent measures of cerebral perfusion and resting state MRI were also collected. Based on previous studies in HC and other patient samples (Li et al, ; Mayer et al, ), we hypothesized that pmTBI patients would exhibit proactive response inhibition deficits (i.e., hyperactivation) in motor circuitry in conjunction with hypoperfusion during the sub‐acute injury phase (within weeks of injury), with both measures recovering at 4 months post‐injury (early chronic visit). We also predicted that these inhibitory motor deficits would be associated with reduced functional connectivity in motor circuitry, as well as being associated with persistent PCS.…”

Section: Introductionmentioning

confidence: 99%

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Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury

Mayer

Stephenson

Wertz

et al. 2019

Human Brain Mapping

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Although much attention has been generated in popular media regarding the deleterious effects of pediatric mild traumatic brain injury (pmTBI), a paucity of empirical evidence exists regarding the natural course of biological recovery. Fifty pmTBI patients (12–18 years old) were consecutively recruited from Emergency Departments and seen approximately 1 week and 4 months post‐injury in this prospective cohort study. Data from 53 sex‐ and age‐matched healthy controls (HC) were also collected. Functional magnetic resonance imaging was obtained during proactive response inhibition and at rest, in conjunction with independent measures of resting cerebral blood flow. High temporal resolution imaging enabled separate modeling of neural responses for preparation and execution of proactive response inhibition. A priori predictions of failed inhibitory responses (i.e., hyperactivation) were observed in motor circuitry (pmTBI>HC) and sensory areas sub‐acutely and at 4 months post‐injury. Paradoxically, pmTBI demonstrated hypoactivation (HC>pmTBI) during target processing, along with decreased activation within prefrontal cognitive control areas. Functional connectivity within motor circuitry at rest suggested that deficits were limited to engagement during the inhibitory task, whereas normal resting cerebral perfusion ruled out deficits in basal perfusion. In conclusion, current results suggest blood oxygen‐level dependent deficits during inhibitory control may exceed commonly held beliefs about physiological recovery following pmTBI, potentially lasting up to 4 months post‐injury.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury

Mayer

Stephenson

Wertz

et al. 2019

Human Brain Mapping

Self Cite

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“…A meta‐analysis [Schaefer, Giangrande, Weinberger, & Dickinson, ] revealed that the effect size for Stroop color‐word condition and Stroop interference was −1.11 and −0.62, respectively. At the neurophysiological and neuroimaging levels, empirical findings also converge to show a significant impairment in response inhibition in SZ patients [Fryer et al, ; Hughes et al, ; Mayer et al, ; Thakkar et al, ]. Moreover, Ettinger et al [], by studying individuals with SZ and their first‐degree relatives, suggested that response inhibition deficits could be a potential endophenotype for SZ.…”

Section: Introductionmentioning

confidence: 99%

“…SZ is a severe psychiatric disorder characterized by positive and negative symptoms and neurocognitive deficits [APA, 2013]. Response inhibition deficits have also been found in SZ patients [Chan, Chen, & Law, 2006;Hughes et al, 2012;Mayer et al, 2016;Thakkar, Schall, Boucher, Logan, & Park, 2011]. For example, one study found that 51 patients with SZ (47 males; mean age = 44 years) required a longer reaction time (RT) for correct responses in the visual response inhibition task, but were no different from typically developing controls in terms of commission error rates [Chan, Chen, Cheung, Chen, & Cheung, 2004].…”

Section: Introductionmentioning

confidence: 99%

Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia

et al. 2019

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Autism spectrum disorders (ASD) and schizophrenia (SZ) are both associated with response inhibition impairment. However, the relative pattern of deficits in these two disorders remains unclear. Twenty‐three male children with ASD, 23 male children with SZ, and 32 typically developing male controls were recruited to complete a set of tasks measuring response inhibition in the visual, auditory, and verbal domains. We found that visual, auditory, and verbal response inhibitions were impaired in both children with ASD and children with SZ. Compared with typically developing controls, children with ASD made more commission errors whereas children with SZ responded much slower in the visual response inhibition task. Both clinical groups showed comparable impairment in verbal response inhibition, but children with SZ were more impaired in auditory response inhibition than children with ASD. These different patterns of response inhibition deficit between male children with ASD and SZ may help to differentiate between these two disorders and may be potential targets for intervention. Autism Res 2020, 13: 591–602. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary In this study, we found that male children with autism spectrum disorder (ASD) made more commission errors whereas male children with schizophrenia (SZ) responded much slower in the visual response inhibition task. Both clinical groups exhibited comparable impairments in verbal response inhibition, but male children with SZ were more impaired in auditory response inhibition than male children with ASD. Our findings provide potential targets for intervention.

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Multimodal Neuroimaging in Schizophrenia: Description and Dissemination

et al. 2017

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In this paper we describe an open-access collection of multimodal neuroimaging data in schizophrenia for release to the community. Data were acquired from approximately 100 patients with schizophrenia and 100 age-matched controls during rest as well as several task activation paradigms targeting a hierarchy of cognitive constructs. Neuroimaging data include structural MRI, functional MRI, diffusion MRI, MR spectroscopic imaging, and magnetoencephalography. For three of the hypothesis-driven projects, task activation paradigms were acquired on subsets of ~200 volunteers which examined a range of sensory and cognitive processes (e.g., auditory sensory gating, auditory/visual multisensory integration, visual transverse patterning). Neuropsychological data were also acquired and genetic material via saliva samples were collected from most of the participants and have been typed for both genome-wide polymorphism data as well as genome-wide methylation data. Some results are also presented from the individual studies as well as from our data-driven multimodal analyses (e.g., multimodal examinations of network structure and network dynamics and multitask fMRI data analysis across projects). All data will be released through the Mind Research Network’s collaborative informatics and neuroimaging suite (COINS).Electronic supplementary materialThe online version of this article (doi:10.1007/s12021-017-9338-9) contains supplementary material, which is available to authorized users.

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Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia

Cited by 18 publications

References 64 publications

Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury

Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury

Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia

Multimodal Neuroimaging in Schizophrenia: Description and Dissemination

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