Concerning the uneven distribution of energy in Chinas regional power grid, power of big energy base should be transmitted through long distance. Therefore, calculating available transfer capability (ATC) of large interconnected grid is necessary. However, it is difficult to collect the needed data, so ATC of the large interconnected grid cannot be calculated directly. To solve these problems, this paper presents a decomposition calculation method to calculate ATC of the large interconnected grid. The basic principles are: According to the executive partition, the large interconnected grid is divided into several subsystems, of which ATC can be calculated directly and easily. Then, according to series or parallel combination between the subsystems, ATC of the large interconnected grid can be calculated indirectly by the obtained ATC of subsystems. The series and parallel ATC probabilistic calculation models are established, used for synthetizing ATC of the subsystems. Illustrations verify the correctness and feasibility of the calculation method.