Probable acute Epstein–Barr virus encephalitis in a 6‐year‐old girl

MacDonald, B.; Diamond, Yonatan; McCloskey, Kate; Standish, Jane

doi:10.1111/jpc.13642

J Paediatrics Child Health

2017

DOI: 10.1111/jpc.13642

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Probable acute Epstein–Barr virus encephalitis in a 6‐year‐old girl

B. MacDonald

Yonatan Diamond

Kate McCloskey

et al.

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2023

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Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years

Peuchmaur,

Voisin,

Vaillant

et al. 2023

Microorganisms

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Although uncommon, Epstein-Barr virus-related neurological disorders represent the seventh most frequent cause of infectious encephalitis in adults. The limited number of publications on EBV encephalitis mainly document isolated clinical cases. This study aimed to summarize published data on EBV encephalitis. A systematic literature search identified 97 EBV encephalitis cases. In the selected cases, EBV-related neurological disorders manifested as lymphocytic pleocytosis in the cerebrospinal fluid (CSF) with moderate hyperproteinorachia. The EBV PCR test was positive in 87% of the CSF samples, with wide-ranging viral loads. When encephalitis occurred in the context of past EBV infections, all of the EBV PCR tests on CSF samples were positive. On the contrary, negative EBV PCR tests on CSF samples occurred only in the context of primary infections. EBV PCR was rarely carried out on blood samples, contributing minimally to the diagnosis. For the treatment of EBV encephalitis, Aciclovir was used alone in 29% of cases, and in association with other drugs in 40% of cases. Ganciclovir (30%), corticoids (52%), and immunoglobulins (15%) were mainly used in association with other drugs. Cerebral imaging was abnormal in 69% of cases, mostly in the cerebellum and basal ganglia. This work highlights that the EBV PCR test on CSF samples is currently the main laboratory diagnostic test to diagnose EBV encephalitis. This diagnostic test is useful; however, it is imperfect. New complementary diagnostic tools, approved treatments, and standardized practices could improve patient management.

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Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years

Peuchmaur,

Voisin,

Vaillant

et al. 2023

Microorganisms

View full text Add to dashboard Cite

show abstract

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Probable acute Epstein–Barr virus encephalitis in a 6‐year‐old girl

Cited by 1 publication

References 8 publications

Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years

Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years

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