Probing magnetic fields on crystals of the nanomagnet Mn12-acetate by electron paramagnetic resonance

Rakvin, Boris; Žilić, Dijana; North, J. M.; Dalal, Naresh S.

doi:10.1016/j.jmr.2003.08.010

Cited by 5 publications

(5 citation statements)

References 39 publications

(35 reference statements)

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“…3). This characteristic of the exchange interaction has also been noted for other organic crystal probes, the DPPH crystal-containing solvent molecule (CS 2 ) [12], the α,γ-bisdiphenylene-βphenylallyl (BDPA) crystal and the previously studied TCNQ poly-crystal [6,8]. Thus, SMM crystals with a broad distribution of local fields at the surface that exhibit space inhomogeneity at the nano scale could be used as possible devices for the investigation of the exchange interaction in organic-type paramagnetic crystals.…”

Section: Discussionsupporting

confidence: 53%

“…Electron Paramagnetic Resonance (EPR) spectroscopy with a local paramagnetic probe will be employed as an alternative simple detection method. As shown recently [6,7,8], an EPR technique in combination with several characteristic paramagnetic probes shows a reliable capability for such measurements for the most common EPR spectrometers involving magnetic field ∼0.35 T with corresponding X-band frequency (∼9.5 GHz). An additional characteristic of this detection is related to the possibility of deducing a time-dependent fluctuation of the local field in a short time scale [6].…”

Section: Introductionmentioning

confidence: 81%

“…Thus, the effect of magnetic-field fluctuation will be detected as the distribution of nearly static magnetic field components. It was shown earlier [7,8] that the characteristic shoulders of the complex powder spectrum of the probe depend on the SMM orientation in the magnetic field. These shoulders exhibited temperature-dependent shifts, which correlated with SQUID measured magnetization of the SMM for the givens orientation in the magnetic field.…”

Section: Introductionmentioning

confidence: 91%

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Study of the local field distribution on a single-molecule magnet by a single paramagnetic crystal: A DPPH crystal on the surface of an Mn12-acetate crystal

Žilić

Rakvin

Dalal

2011

Journal of Applied Physics

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The local magnetic field distribution on the subsurface of a single-molecule magnet crystal, SMM, above blocking temperature (T >> T b ) detected for a very short time interval (∼ 10 −10 s), has been investigated. Electron Paramagnetic Resonance (EPR) spectroscopy using a local paramagnetic probe was employed as a simple alternative detection method. An SMM crystal of [Mn 12 O 12 (CH 3 COO) 16 (H 2 O) 4 ]•2CH 3 COOH•4H 2 O (Mn 12 -acetate) and a crystal of 2,2diphenyl-1-picrylhydrazyl (DPPH) as the paramagnetic probe were chosen for this study. The EPR spectra of DPPH deposited on Mn 12 -acetate show additional broadening and shifting in the magnetic field in comparison to the spectra of the DPPH in the absence of the SMM crystal. The additional broadening of the DPPH linewidth was considered in terms of the two dominant electron spin interactions (dipolar and exchange) and the local magnetic field distribution on the crystal surface. The temperature dependence of the linewidth of the Gaussian distribution of local fields at the SMM surface was extrapolated for the low temperature interval (70-5 K).

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 91%

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Study of the local field distribution on a single-molecule magnet by a single paramagnetic crystal: A DPPH crystal on the surface of an Mn12-acetate crystal

Žilić

Rakvin

Dalal

2011

Journal of Applied Physics

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“…Manganese-12 acetate (Mn12Ac) is a magnetically bistable molecule exhibiting a combination of strong magnetic anisotropy and high spin properties ( 10 , 11 ). However, there have been no studies concerning the association between Mn12Ac and disease therapy, particularly in cancer.…”

Section: Introductionmentioning

confidence: 99%

Mn12Ac inhibits the migration, invasion and epithelial‑mesenchymal transition of lung cancer cells by downregulating the Wnt/β‑catenin and PI3K/AKT signaling pathways

Chen

Xing

et al. 2018

Oncol Lett

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Lung cancer is the leading cause of global cancer-associated mortality, therefore it is important to reveal the molecular mechanisms of lung cancer progression and to develop novel therapeutic targets. The results of the present study identified that manganese-12 acetate (Mn12Ac) was able to significantly inhibit the migration and invasion of A549 cells. Western blotting demonstrated that treatment with Mn12Ac was able to upregulate E-cadherin, and downregulate N-cadherin and vimentin. It was also identified by a quantitative polymerase chain reaction analysis that Mn12Ac was able to reduce the mRNA expression levels of EMT-associated transcription factors Snail, Slug, Twist-related protein 1 and zinc finger E-box-binding homeobox 1. It was also demonstrated that Mn12Ac was able to reduce the expression levels of Wnt and β-catenin proteins, and suppress the phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT in A549 cells. Notably, it was revealed that Mn12Ac was able to decrease the mRNA and protein expression levels of programmed death ligand-1. Taken together, the results suggested that Mn12Ac is able to inhibit cell migration, invasion and EMT in lung cancer cells by regulating the Wnt/β-catenin and PI3K/AKT signaling pathways.

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“…Manganese‐12 acetate (Mn12Ac) is a magnetically bistable molecule showing a combination of strong magnetic anisotropy and high spin properties . However, there has been no report about the correlations between Mn12Ac and disease therapy, especially cancer.…”

Section: Introductionmentioning

confidence: 99%

Manganese‐12 acetate suppresses the migration, invasion, and epithelial–mesenchymal transition by inhibiting Wnt/β‐catenin and PI3K/AKT signaling pathways in breast cancer cells

Xing

et al. 2018

Thoracic Cancer

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BackgroundBreast cancer is the leading cause of cancer‐related death in the world, and it is of great value to reveal the molecular mechanisms of breast cancer progression and develop new therapeutic targets.MethodsTranswell assay is used to analyze the migration and invasion of breast cancer cells. Real‐time PCR and western blotting assay are applied to detect the expression levels of epithelial–mesenchymal transition markers and the key members of Wnt/β‐catenin and PI3K/AKT signaling pathways.ResultsManganese‐12 acetate (Mn12Ac) significantly inhibited the migration and invasion of MCF7 and MDA‐MB‐231 breast cancer cells. Western blotting assay further showed that Mn12Ac significantly upregulated E‐cadherin, and downregulated N‐cadherin and vimentin. We further found that Mn12Ac reduced the mRNA expressions of epithelial–mesenchymal transition‐associated transcription factors snail, slug, twist1, and ZEB1 using real‐time PCR assay. Importantly, we further found that Mn12Ac significantly reduced the Wnt1 and β‐catenin protein expressions, and suppressed the phosphorylation of PI3K and AKT in MCF7 and MDA‐MB‐231 breast cancer cells. Very interestingly, we also showed that Mn12Ac decreased the mRNA and protein expressions of programmed cell death ligand 1.ConclusionTaken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial–mesenchymal transition by regulating Wnt/β‐catenin and PI3K/AKT signaling pathways in breast cancer.

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Probing magnetic fields on crystals of the nanomagnet Mn12-acetate by electron paramagnetic resonance

Cited by 5 publications

References 39 publications

Study of the local field distribution on a single-molecule magnet by a single paramagnetic crystal: A DPPH crystal on the surface of an Mn12-acetate crystal

Study of the local field distribution on a single-molecule magnet by a single paramagnetic crystal: A DPPH crystal on the surface of an Mn12-acetate crystal

Mn12Ac inhibits the migration, invasion and epithelial‑mesenchymal transition of lung cancer cells by downregulating the Wnt/β‑catenin and PI3K/AKT signaling pathways

Manganese‐12 acetate suppresses the migration, invasion, and epithelial–mesenchymal transition by inhibiting Wnt/β‐catenin and PI3K/AKT signaling pathways in breast cancer cells

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