Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils

Jayapaul, Jabadurai; Schröder, Leif

doi:10.3390/molecules25040957

Cited by 13 publications

(5 citation statements)

References 219 publications

(485 reference statements)

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“…Notably, the IDA format is also applicable to other signal transduction methods besides absorbance and fluorescence spectroscopy. For instance, 129 Xe can be used as an NMR indicator to follow in vitro and in vivo binding of spectroscopically silent analytes to CB6 and CB7, as has been demonstrated by the Dmochowski group, the Albert group, and by Schröder, Hennig, and coworkers. − …”

Section: Amino Acidsmentioning

confidence: 96%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

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Section: Amino Acidsmentioning

confidence: 96%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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“…However, their commercial unavailability, complex synthesis involving multiple steps, and low yields pose some challenges. While cryptophane-A is difficult to synthesize, the biocompatible and readily available cucurbit [6]uril [104,167,168] has been recognized as a promising alternative. In the next subsection, we delve into cucurbit [6]uril's biosensing properties.…”

Section: Hypercest Approaches Utilizing Cra-based Agentsmentioning

confidence: 99%

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Batarchuk,

Shepelytskyi,

Grynko

et al. 2024

IJMS

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Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide range of hyperpolarized (HP) 129Xe biosensors have been recently developed, demonstrating their potential applications in molecular settings, and achieving notable success within in vitro studies. The favorable nuclear magnetic resonance properties of 129Xe, coupled with its non-toxic nature, high solubility in biological tissues, and capacity to dissolve in blood and diffuse across membranes, highlight its superior role for applications in molecular MRI settings. The incorporation of reporters that combine signal enhancement from both hyperpolarized 129Xe and chemical exchange saturation transfer holds the potential to address the primary limitation of low sensitivity observed in conventional MRI. This review provides a summary of the various applications of HP 129Xe biosensors developed over the last decade, specifically highlighting their use in MRI. Moreover, this paper addresses the evolution of in vivo applications of HP 129Xe, discussing its potential transition into clinical settings.

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“…Naturally, this is reflected in its NMR signal, which, analogously to solid materials, can be used to obtain in-depth structural and morphological information along with knowledge about phase separation, dynamics, and presence and size of different domains. Owing to these important features, 129 Xe NMR has been used to study a variety of pure liquids, mixtures, solutions, and host-guest complexes in the liquid phase [51][52][53][54][55][56][57].…”

Section: Liquids Mixtures and Solutionsmentioning

confidence: 99%

129Xe: A Wide-Ranging NMR Probe for Multiscale Structures

2022

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Porous materials are ubiquitous systems with a large variety of applications from catalysis to polymer science, from soil to life science, from separation to building materials. Many relevant systems of biological or synthetic origin exhibit a hierarchy, defined as spatial organization over several length scales. Their characterization is often elusive, since many techniques can only be employed to probe a single length scale, like the nanometric or the micrometric levels. Moreover, some multiscale systems lack tridimensional order, further reducing the possibilities of investigation. 129Xe nuclear magnetic resonance (NMR) provides a unique and comprehensive description of multiscale porous materials by exploiting the adsorption and diffusion of xenon atoms. NMR parameters like chemical shift, relaxation times, and diffusion coefficient allow the probing of structures from a few angstroms to microns at the same time. Xenon can evaluate the size and shape of a variety of accessible volumes such as pores, layers, and tunnels, and the chemical nature of their surface. The dynamic nature of the probe provides a simultaneous exploration of different scales, informing on complex features such as the relative accessibility of different populations of pores. In this review, the basic principles of this technique will be presented along with some selected applications, focusing on its ability to characterize multiscale materials.

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Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils

Cited by 13 publications

References 219 publications

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

129Xe: A Wide-Ranging NMR Probe for Multiscale Structures

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