Probing the charm Yukawa coupling at future 
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Li, Ruibo; Wang, Bowen; Wang, Kai; Zhang, Xiaoyuan; Zhou, Zhenyu

doi:10.1103/physrevd.100.053008

Cited by 9 publications

(4 citation statements)

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“…In this instance, the free thiol-terminated DOX generated via reduction could potentially rebind to the QD surface, maintaining efficient FRET. 47 Quantification and Optimization of Cellular Uptake of QD−JB434 Conjugates. Having confirmed the controlled assembly of the complexes and the functionality of the various chemical linkages, we next sought to determine the optimal QD concentration required for uptake and visualization of the QD− peptide complexes in living HeLa cells.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Intracellularly Actuated Quantum Dot–Peptide–Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway

Sangtani

Petryayeva

et al. 2017

Bioconjugate Chem.

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Nanoparticle (NP)-mediated drug delivery (NMDD) has emerged as a novel method to overcome the limitations of traditional systemic delivery of therapeutics, including the controlled release of the NP-associated drug cargo. Currently, our most advanced understanding of how to control NP-associated cargos is in the context of soft nanoparticles (e.g., liposomes), but less is known about controlling the release of cargos from the surface of hard NPs (e.g., gold NPs). Here we employ a semiconductor quantum dot (QD) as a prototypical hard NP platform and use intracellularly triggered actuation to achieve spatiotemporal control of drug release and modulation of drug efficacy. Conjugated to the QD are two peptides: (1) a cell-penetrating peptide (CPP) that facilitates uptake of the conjugate into the endocytic pathway and (2) a display peptide conjugated to doxorubicin (DOX) via three different linkages (ester, disulfide, and hydrazone) that are responsive to enzymatic cleavage, reducing conditions, and low pH, respectively. Formation of the QD-[peptide-DOX]-CPP complex is driven by self-assembly that allows control over both the ratio of each peptide species conjugated to the QD and the eventual drug dose delivered to cells. Förster resonance energy transfer assays confirmed successful assembly of the QD-peptide complexes and functionality of the linkages. Confocal microscopy was employed to visualize residence of the QD-[peptide-DOX]-CPP complexes in the endocytic pathway, and distinct differences in DOX localization were noted for the ester linkage, which showed clear signs of nuclear delivery versus the hydrazone, disulfide, and amide control. Finally, delivery of the QD-[peptide-DOX]-CPP conjugate resulted in cytotoxicity for the ester linkage that was comparable to free DOX. Attachment of DOX via the hydrazone linkage facilitated intermediary toxicity, while the disulfide and amide control linkages showed minimal toxicity. Our data demonstrate the utility of hard NP-peptide bioconjugates to function as multifunctional scaffolds for simultaneous control over cellular drug uptake and toxicity and the vital role played by the nature of the chemical linkage that appends the drug to the NP carrier.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Intracellularly Actuated Quantum Dot–Peptide–Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway

Sangtani

Petryayeva

et al. 2017

Bioconjugate Chem.

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“…In practice, however, the Lorentz symmetry is broken by the Fock-sector truncation in our model [42][43][44]. 4 The frame dependence of the Dirac form factor could hence serve as a measure of the Lorentz symmetry violation, which will be the topic of a future work.…”

Section: Dirac Form Factormentioning

confidence: 99%

Basis light-front quantization for a chiral nucleon-pion Lagrangian

Zhao

et al. 2020

Phys. Rev. C

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We present the first application of the Basis Light-Front Quantization method to a simple chiral model of the nucleon-pion system as a relativistic bound state for the physical proton. The light-front mass-squared matrix of the nucleon-pion system is obtained within a truncated basis. The mass and the corresponding light-front wave function (LFWF) of the proton are computed by numerical diagonalization of the resulting mass-squared matrix. With the boost invariant LFWF, we calculate the probability density distribution of the pion's longitudinal momentum fraction and the Dirac form factor of the proton. * BLFQ employs the LF formalism [18,19], where physical systems are quantized at fixed LF time x + = t+z [8,20]. The structure and dynamics of the systems are characterized by the Hamiltonian formalism. The LF vacuum has a simple structure since the Fock vacuum is an exact eigenstate of the full normal-ordered Hamiltonian [21,22]. This provides access to the Fock-space expansion of the physical states in the LF field theory and thereby generates physical intuition for their underlying structures [21,22].BLFQ also takes the advantage of the developments in ab initio non-relativistic quantum many-body theories, such as the No-Core Shell Model (NCSM) [23][24][25], and the rapidly developing supercomputing techniques (algorithms and hardwares) (see, e.g., [26] and references therein). In BLFQ, the LF mass-squared operator of a hadron system in the basis representation becomes a sparse matrix whose dimensions are controlled by truncations that respect the relativistic symmetries. By matrix diagonalization, the eigenvalues produce the mass sprectum, while the resulting eigenfunctions are the light-front wave functions (LFWFs) that encode the hadronic properties. The LFWFs can be boosted to a general Lorentz frame for calculating, e.g., form factors and scattering processes [21].The LF quantization approach to treat a chiral model of the nucleon-pion (N π) system was first proposed by Miller [27,28] in investigating the N π scattering and the nucleon-nucleon scattering via perturbation theory. In this work, we will present the first non-perturbative treatment of the same chiral model via the BLFQ method. In particular, we consider a physical proton as the relativistic bound state of the N π system. Via the BLFQ approach, we obtain the LF mass-squared matrix of the N π system within a truncated basis. We compute the proton's mass and the corresponding LFWF by numerical diagonalization of the mass-squared matrix. Based on the LFWF, we evaluate the probability density distribution of the pion's longitudinal momentum fraction and the Dirac form factor of the proton.The outline of this paper is the following. We begin by introducing our adopted Lagrangian density in Sec. 2. Then, in Sec. 3, we introduce the elements of BLFQ, such as the derivation of the LF Hamiltonian density, our choice of the basis construction and truncation schemes, the derivation of the mass-squared matrix element in the basis representation, and the fo...

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“…For comparison we add the BBP y and the f y which are not in use here It is known that different directions of an outer force can change the kind of the reaction path. [23,41,43,53,54,[77][78][79][80][81] This one applied to our model system means that the external force could be applied either in the x-or in the y-direction. However, pulling along the symmetric…”

Section: Model Pes For Pulling a Linear Abc Moleculementioning

confidence: 99%

Toward a theory of mechanochemistry: Simple models from the very beginnings

Quapp

Bofill

Ribas‐Ariño

2018

Int J of Quantum Chemistry

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A core idea in the context of mechanochemistry is that applying an external tensile force along a reaction coordinate should enhance the chemical reaction of interest. Here, we analyze perturbed generic molecular structures: schematic models of triatomics, ABC, and tetraatomics, AABB. They are used to demonstrate that pulling does usually not use the “reaction coordinate,” but opens new reaction pathways. Within development of these models we use the concept of Newton trajectories for a theory of mechanochemistry. However, we find cases where the theory of Newton trajectories is not applicable. For all cases, we define the curve of force‐displaced stationary points, and we discuss the importance of barrier breakdown points and valley‐ridge inflection points. The examples use Morse potentials for bonds and simple angle functions and are demonstrated by assumed real values for the potential parameters. On the basis of the systematic study of some generic models we explain a set of already observed experimental mechanochemical phenomena in specific molecular systems and we apply the results to the strength of chemical bonds.

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Probing the charm Yukawa coupling at future e−p and e+e−

Cited by 9 publications

References 50 publications

Intracellularly Actuated Quantum Dot–Peptide–Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway

Intracellularly Actuated Quantum Dot–Peptide–Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway

Basis light-front quantization for a chiral nucleon-pion Lagrangian

Toward a theory of mechanochemistry: Simple models from the very beginnings

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