2023
DOI: 10.1101/2023.09.01.555951
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Probing the stability and interdomain interactions in the ABC transporter OpuA, using single-molecule optical tweezers

Lyan van der Sleen,
Jan Stevens,
Siewert J. Marrink
et al.

Abstract: Transmembrane transporter proteins are essential for the maintenance of cellular homeostasis and, as such, are key drug targets. Many transmembrane transporter proteins are known to undergo large structural rearrangements during their functional cycles. Despite the large amount of detailed structural and functional data available for these systems, our understanding of their dynamics and therefore how they function is generally limited. We introduce an innovative approach which enables us to directly measure t… Show more

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