Probiotic Bifidobacteria Protect Mice from Lethal Infection with Shiga Toxin-Producing
            <i>Escherichia coli</i>
            O157:H7

Asahara, Takashi; Shimizu, Kensuke; Nomoto, Koji; Hamabata, Takashi; Ozawa, Ayako; Takeda, Yasuharu

doi:10.1128/iai.72.4.2240-2247.2004

Cited by 260 publications

(176 citation statements)

References 38 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…B. breve strain yakult and Lb. casei resulted in the protection of mice from lethal STEC infections by inhibiting the production of Shiga toxin (Stx) in the intestine [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Feeding Probiotics on Rats' Immunity and Health Conditions during Pregnancy

Ali¹,

Metwally²,

Mahmoud³

et al. 2011

FNS

View full text Add to dashboard Cite

show abstract

“…B. breve strain yakult and Lb. casei resulted in the protection of mice from lethal STEC infections by inhibiting the production of Shiga toxin (Stx) in the intestine [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Feeding Probiotics on Rats' Immunity and Health Conditions during Pregnancy

Ali¹,

Metwally²,

Mahmoud³

et al. 2011

FNS

View full text Add to dashboard Cite

show abstract

“…Probiotics can exert a direct antimicrobial ability by producing inhibitory substances such as organic acids and bacteriocins, peptides with a potent antibacterial property [127,128]. Lactobacillus and Bifidobacterium spp.…”

Section: Probioticsmentioning

confidence: 99%

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Lee¹,

Serre²

2015

JNHFS

View full text Add to dashboard Cite

cell injury [6], metabolic regulation [7], GI tract development [8], innate and adaptive immune responses, and absorption of nutrients [9,10]. Alterations in microbiota composition and dysregulation of the intestinal mucosa homeostasis have been implicated in the development and progression of pathologies. This compositional change in the microbiota and/ or an abnormality in the interactions between the host and the commensal microbiota is referred to as dysbiosis. Gut microbiota dysbiosis has been linked to chronic low-grade intestinal inflammation and acute intestinal autoimmunity diseases such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) [11,12]. Abnormal microbiota composition is associated with a wide range of metabolic and behavioral disorders, such as anxiety/depression [13][14][15] [26]. GI microbiota dysbiosis might also be involved in the development and persistence of systemic disorders [27]. For example, obesity has been characterized by a decrease in overall diversity [28] and an increase in Proteobacteria abundance and in the Firmicutes to Bacteroidetes ratio [28,29] and microbiota composition is believed to influence energy balance and glucose homeostasis [30][31][32].Evidence that changes in microbiota composition are correlated with metabolic and behavioral disorders has drawn attention to a potential causal role for the microbiota in pathologies and has led to the emergence of the 'microbiota-gutbrain axis' concept [33][34][35]. The gut-brain axis is a bidirectional communication system between the GI tract and the brain [36] via hormonal, immunological, and neural signaling. Information from the GI tract and the intestinal microbiota can reach the peripheral and Central Nervous System (CNS), concurrently the brain is able to influence GI functions such as motility and secretion but also immune responses and cytokine production [36,37]. The Microbiota-Gut-Brain AxisThe gut microbiota can modulate gut-brain axis signaling via direct and indirect mechanisms. The microbiota acts via endocrine, metabolic (bacterial components and metabolites), AbstractThe human gut microbiota contains more than 100 trillion bacteria that, under normal physiological conditions, have beneficial symbiotic interactions with the host. However, a growing body of evidence has shown that alternations in the composition and diversity of the gut microbiota, or dysbiosis, can influence the development and progress of metabolic and neurological disorders. Communication between the microbiota and the brain is a bidirectional system involving endocrine, metabolic (bacterial components and metabolites), immune, and neural pathways. Gut microbiota composition influences the signals transmitted from the gut to the brain. Alternatively, the brain utilizes similar mechanisms, in particular endocrine and neural signaling, to modulate the composition of the gut bacteria. In this review, we describe the recent evidence of gut microbiota interaction with the central nervous system to influence physiological a...

show abstract

“…Bifidobacteria have been used for many years as supplements to promote host wellbeing, as their presence, including the high levels observed in infants and stable levels in adults, is associated with a 'healthy' state. These bacteria are particularly effective at protecting against infectious diseases [4][5][6][7] and modulating immune responses [7,8]. This review discusses Bifidobacterium across the life course, and focuses on species and specific strains that have been studied in the context of immune modulation and treatment of disease.…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases

O’Neill

Schofield

Hall

2017

Emerging Topics in Life Sciences

View full text Add to dashboard Cite

The gut-associated microbiota is essential for multiple physiological processes, including immune development. Acquisition of our initial pioneer microbial communities, including the dominant early life genus Bifidobacterium, occurs at a critical period of immune maturation and programming. Bifidobacteria are resident microbiota members throughout our lifetime and have been shown to modulate specific immune cells and pathways. Notably, reductions in this genus have been associated with several diseases, including inflammatory bowel disease. In this review, we provide an overview of bifidobacteria profiles throughout life and how different strains of bifidobacteria have been implicated in immune modulation in disease states. The focus will be examining preclinical models and outcomes from clinical trials on immune-linked chronic conditions. Finally, we highlight some of the important unresolved questions in relation to Bifidobacterium-mediated immune modulation and implications for future directions, trials, and development of new therapies.

show abstract

Probiotic Bifidobacteria Protect Mice from Lethal Infection with Shiga Toxin-Producing Escherichia coli O157:H7

Cited by 260 publications

References 38 publications

Effect of Feeding Probiotics on Rats' Immunity and Health Conditions during Pregnancy

Effect of Feeding Probiotics on Rats' Immunity and Health Conditions during Pregnancy

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases

Contact Info

Product

Resources

About