2022
DOI: 10.3233/jad-215025
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Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse1

Abstract: Background: Probiotic supplementation reestablishes microbiome diversity and improves brain function in Alzheimer’s disease (AD); their molecular mechanisms, however, have not yet been fully illustrated. Objective: We investigated the effects of orally supplemented Bifidobacterium breve MCC1274 on cognitive function and AD-like pathologies in AppNL-G-F mice. Methods: Three-month-old AppNL-G-F mice were orally supplemented with B. breve MCC1274 for four months. The short-term memory function was evaluated using… Show more

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Cited by 34 publications
(61 citation statements)
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“…In contrast to the hippocampus, these protein levels did not change in the cortical extracts between the two groups (Figure 6B). These findings indicate that B. breve MCC1274 supplementation increases the expression of synaptic proteins in WT mice, which is consistent with previous findings that B. breve MCC1274 supplementation increases these synaptic protein levels in App NL-G-F mice [27].…”
Section: B Breve Mcc1274 Supplementation Enhances Synaptic Plasticity...supporting
confidence: 93%
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“…In contrast to the hippocampus, these protein levels did not change in the cortical extracts between the two groups (Figure 6B). These findings indicate that B. breve MCC1274 supplementation increases the expression of synaptic proteins in WT mice, which is consistent with previous findings that B. breve MCC1274 supplementation increases these synaptic protein levels in App NL-G-F mice [27].…”
Section: B Breve Mcc1274 Supplementation Enhances Synaptic Plasticity...supporting
confidence: 93%
“…Unfortunately, their mRNA levels were undetectable, even in the saline-supplemented group (data not shown), possibly because neuroinflammation had not occurred because the mice were still young. These results suggest that B. breve MCC1274 supplementation in WT mice attenuates microglial activation only in the hippocampus, and does not affect reactive astrocytes, which is consistent with previous findings in App NL-G-F mice [27].…”
Section: B Breve Mcc1274 Supplementation Attenuated Microglial Activa...supporting
confidence: 92%
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