Probiotics: a new or an old concept?

Захаренко, С. М.

doi:10.21518/2079-701x-2018-14-56-60

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Among the inhibitors found, there are both moderately toxic and non-toxic compounds. Usnic acid, coumarin, and adamantan derivatives proved to be sensitizers of the tumor cell lines to top1 poison topotecan, with twofold enhancement of cytotoxicity of topotecan [3][4][5][6]. Conclusion: the compounds studied can be used to develop on their basis effective sensitizers of malignant cells to top1 poisons.…”

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confidence: 99%

Development of Tdp1 inhibitors based on natural biologically active compounds as prototypes of antitumor drugs

2019

The Eleventh International Young Scientists School

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Key words: tyrosyl-dNAphosphodiesterase I, inhibitor of tyrosyl-dNA phosphodiesterase I Motivation and Aim: developing inhibitors for dNA repair enzymes is a promising approach to improve anticancer therapy, in particular for drug-resistant tumors. tdp1 plays a key role in the repair of top1-dNA covalent complexes formed by topoisomerase-1 (top1) poisons such as drugs of the camptothecin group, which makes it a promising target in the treatment of cancer [1]. the development of new inhibitors of dNA repair enzymes based on natural compounds and their derivatives is particularly relevant, since such compounds often have complementarity to targets of biological origin and possess broad range of biological activities. Methods and Algorithms: Screening of compounds -potential inhibitors is carried out using a real-time fluorescence measurement method, which makes it possible to determine the initial reaction rate with high accuracy [2]. the effect of the selected compounds on the proliferation of transplanted tumor cell lines and the evaluation of cell death are studied using the mtt test. We used derivatives of usnic acid, coumarin and

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confidence: 99%

Development of Tdp1 inhibitors based on natural biologically active compounds as prototypes of antitumor drugs

2019

The Eleventh International Young Scientists School

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Probiotics – a new panacea for periodontal diseases?! Literature review

Taimazova,

Choniashvili,

Avanisyan

et al. 2023

Medicinskij alfavit

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Introduction. The emergence of new antibiotic-resistant strains of microorganisms, the widespread spread of viral and fungal diseases, as well as the growing allergisation of the population have generated interest in bacterial preparations – probiotics, which include living microorganisms – representatives, as a rule, of the obligate human microflora, which, when ingested in sufficient quantities, enter the body, retain their activity and viability, have a positive effect on the patient’s health.The purpose of the study was to review the literature on this topic, to determine the concepts of the use of probiotics in dentistry, as well as to identify promising directions in the development of methods of therapy of periodontal diseases with their use.Materials and methods. When studying this issue, scientific sources indexed in the Higher Attestation Commission, Scopus and Web of Sciences were analyzed.Results. Probiotics are a recognized therapeutic adjunct for various generalized and systemic diseases of the oral cavity. Their role in the prevention and treatment of dental caries, as well as its complications, is a direction that has been studied quite fully in the last two decades. The evidence for this is reflected in many randomized control studies. To test various probiotic combinations, it is necessary to conduct multicenter studies so that patients can take advantage of the entire therapeutic spectrum of new drugs based on probiotics and synbiotics.

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The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

et al. 2020

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Relevance. A long-term inflammation in the oral cavity, unreasonable treatment of periodontal patients with antibiotics cause imbalance between certain types of fungal-bacterial associations accompanied by oral dysbiosis and change of local immune status. So, development and application of new comprehensive diagnosis and treatment techniques in periodontal patients, use of products for correction of microbiota and local immunity are a current and a long-term task. Purpose is to optimize the comprehensive treatment protocol of inflammatory periodontal diseases by introducing probiotics and evaluation of oral microbiome and cytokine profile.Materials and methods. 140 patients were examined. Of these 60 patients had chronic generalized plaque-induced gingivitis and 60 patients suffered from moderate chronic generalized periodontitis. Bacterial and fungal microbiome was assessed and the host immune response was evaluated in all patients before and after the treatment. Half of the patients were treated conventionally and the other half were treated according to a modified scheme: probiotic “Bifidumbacterin Forte” was added.Results. A large number of yeast-like fungi Candida and commensal bacteria were detected in periodontal pockets of patients with chronic generalized plaque-induced gingivitis and moderate chronic generalized periodontitis. That correlates with a significant increase of pro-inflammatory cytokines (TNF-α, IL—8), decrease of concentration of INF-γ and increase of antiinflammatory cytokine IL-4.Conclusion. Changes in clinical, microbiological and immunological values during a modified combination therapy with a probiotic and during a conventional treatment demonstrated that effectiveness of treatment of chronic gingivitis and chronic periodontitis increased by 40% and 37% respectively.

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Probiotics: a new or an old concept?

Cited by 4 publications

References 24 publications

Development of Tdp1 inhibitors based on natural biologically active compounds as prototypes of antitumor drugs

Development of Tdp1 inhibitors based on natural biologically active compounds as prototypes of antitumor drugs

Probiotics – a new panacea for periodontal diseases?! Literature review

The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

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