Probiotics and oral healthcare

Teughels, Wim; Essche, Mark Van; Sliepen, I.; Quirynen, Marc

doi:10.1111/j.1600-0757.2008.00254.x

Cited by 138 publications

(114 citation statements)

References 206 publications

(246 reference statements)

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“…It is generally thought that there are combined local and systemic effects involving adhesion, co-aggregation, competitive inhibition, production of organic acids and bacteriocin-like compounds, and immune-modulation. 2,3 Although these events have been convincingly demonstrated in the laboratory environment, studies of complex biofilm models or in vivo are still scarce. Moreover, the Human Microbiome Project showed that 75 to 100 species of bacteria predominate in each person's mouth, but different people have different combinations of species, insofar as it was found that some of the species prevailing in one person's mouth were rare in another's mouth.…”

Section: Discussionmentioning

confidence: 99%

“…The most common probiotic bacteria belong to the lactobacilli and bifidobacteria genera, but certain strains of streptococci have also been investigated. 3 Lactobacilli are highly acidogenic and aciduric, and grow optimally under slightly acidic conditions. They are considered a part of the normal oral flora and comprise about 1% of the cultivable species.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…6,7 Laboratory and animal studies Several experimental studies have recently been performed with the main purpose of investigating various biochemical properties of probiotic bacteria and their interaction with oral bacteria in planktonic cultures or in biofilm models. For example, studies on metabolic activity, 8 co-aggregation, 9 growth inhibition, 10 bacteriocin production, 3 binding to oral structures, saliva and biofilm formation, 11 have collectively suggested a potential role for probiotic bacteria in modulating the oral microbial ecology. Consequently, the search has started for optimal candidates for the major oral diseases.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

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Are we ready for caries prevention through bacteriotherapy?

Twetman

2012

Braz. oral res.

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Recent insights in medical science indicate that human biofilms play an important role in health and well-being, and have put microbiota modulation through bacteriotherapy into focus. In dentistry, bacterial interference with probiotic bacteria to support the stability and diversity of oral biofilms has gained similar interest. Investigations in vitro into metabolic activity, co-aggregation, growth inhibition, bacteriocin production, and adhesion have collectively suggested a potential role for probiotic lactobacilli and bifidobacteria to modulate the oral microbial ecology. Likewise, short-term clinical studies with intermediate microbial endpoints indicate that interference with caries-associated bacteria seems possible through probiotic dairy products, tablets, lozenges and chewing gum in various dose regimens. Few randomized controlled clinical trials with caries outcomes are available, but three studies with preschool children and the elderly have demonstrated preventive fractions between 21% and 75%, following regular intake of milk supplemented with probiotic lactobacilli. However, further large-scale trials with orally derived anti-caries candidates are needed before we can say that we are ready for bacteriotherapy as an adjunct to complement the existing evidence-based methods for preventing and controlling caries in daily practice.

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Section: Discussionmentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

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Are we ready for caries prevention through bacteriotherapy?

Twetman

2012

Braz. oral res.

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“…Otros factores asociados a este proceso como la dieta, el huésped y el tiempo, son responsables de su aparición; si son interceptados, pueden detener la progresión de la enfermedad (Teughels et al, 2008). Esta enfermedad es frecuente en países en desarrollo como Chile, en donde el acceso a atención dental es limitada y se necesita desarrollar de nuevas medidas preventivas de bajo costobeneficio como el uso de probióticos.…”

Section: Introductionunclassified

Efecto de Dos Probióticos que Contienen Cepas de Lactobacillus casei variedad rhamnosus y Lactobacillus johnsonii sobre el Crecimiento in Vitro de Streptococcus mutans

Rebolledo

Rojas

Salgado

2013

Int. J. Odontostomat.

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REBOLLEDO, M.; ROJAS, E. & SALGADO, F. Efecto de dos probioticos que contienen cepas de RESUMEN:La caries dental es una de las enfermedades mas prevalentes en la población mundial y más aún en los países en desarrollo, por lo que se necesitan nuevas medidas para su prevención. Estudios previos señalan que el efecto de cepas probióticas inhibe la colonización de los patógenos responsables de la caries dental como el Streptococcus mutans, previniendo la aparición de la caries dental. El objetivo fue medir el efecto de las cepas probióticas Lactobacillus casei variedad rhamnosus (LCR32) y Lactobacillus johnsonii (LA1) sobre le crecimiento in vitro de Streptococcus mutans. Se midió el efecto in vitro de las cepas de dos probióticos comercializados en Chile; Lactobacillus casei variedad rhamnosus (LCR32) contenidas en Lactil® y Lactobacillus johnsonii (LA1) contenidas en Chamyto, sobre el crecimiento in vitro de Streptococcus mutans. Se realizaron medios de cultivo selectivos para Streptococcus mutans a los cuales se les adicionaron cuatro diluciones diferentes de cada probiótico y se midió el halo de inhibición de los Streptococcus mutans con un pie de metro. Los probióticos con las cepas Lactobacillus casei variedad rhamnosus (LCR32) y Lactobacillus johnsonii (LA1) inhiben el crecimiento sobre Streptococcus mutans. Ambos probióticos en las dos concentraciones más altas no obtuvieron diferencias significativas en relación a los halos de inhibición. Sin embargo, el probiótico con la cepa Lactobacillus casei variedad rhamnosus (LCR35), mostró halos de inhibición más significativos en comparación a la cepa Lactobacillus johnsonii (LA1). Las cepas probióticas Lactobacillus casei variedad rhamnosus (LCR35) y Lactobacillus Johnosonii (LA1) disminuyen la colonización de las principales bacterias productoras de caries dental, de tal forma estos probióticos podrían ser utilizados como apoyo en la prevención y profilaxis de la enfermedad en pacientes de alto riesgo cariogénico, en forma adicional a otros medios de prevención.

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“…1 Although the mechanism underlying probiotic activity in the oral cavity is not fully understood, it is usually considered to be a combination of local and systemic immune responses as well as non-immunological defense mechanisms. 2 The principal health-promoting effects are ascribed to the ability of probiotics to enhance the intestinal mucosal immune defense and macrophage activity and elevate the numbers of killer cells, T cells, and interferons.…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotic fermented milk on biofilms, oral microbiota, and enamel

et al. 2015

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The aim of this study was to evaluate in vitro and in vivo the effects of 2 brands of probiotic fermented milk on biofilms, oral microbiota, and enamel. For the in situ experiment, ten volunteers wore palatine devices containing four blocks of bovine dental enamel over 3 phases, during which 20% sucrose solution, Yakult ® (Treatment A), and Batavito ® (Treatment B) were dropped on the enamel blocks. Salivary microbial counts were obtained and biofilm samples were analyzed after each phase. For the in vivo experiment, the same ten volunteers drunk Yakult ® (Treatment C) and Batavito ® (Treatment D) in two phases. Saliva samples were collected for microbial analysis after each phase. The in situ study showed that in comparison with Treatment A, Treatment B resulted in fewer total cultivable anaerobes and facultative microorganisms in biofilms, higher final microhardness, lower percentage change in surface hardness, and smaller integrated subsurface enamel hardness. In the in vivo study, Treatment D resulted in a reduction in the counts of all microorganisms. The results suggested that the probiotic fermented milk Batavito ® , but not Yakult ® , reduced the amount of oral microorganisms and mineral loss in bovine enamel.

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Probiotics and oral healthcare

Cited by 138 publications

References 206 publications

Are we ready for caries prevention through bacteriotherapy?

Are we ready for caries prevention through bacteriotherapy?

Efecto de Dos Probióticos que Contienen Cepas de Lactobacillus casei variedad rhamnosus y Lactobacillus johnsonii sobre el Crecimiento in Vitro de Streptococcus mutans

Effects of probiotic fermented milk on biofilms, oral microbiota, and enamel

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