Problems and Prospects of Intermediary Metabolism Correction in Patients With Vascular Comorbidity

Rumyantseva, S. A.; Оганов, Р. Г.; Stupin, Victor; Silina, Ekaterina; Орлова, А. С.; Bolevich, Sergey; Afanas'ev, V V; Кабаева, Е. Н.; Volik, Stas

doi:10.20996/1819-6446-2013-9-3-316-322

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…For that reason, any disturbance of the oxygen supply to cells leads to a several-fold reduction of ATP synthesis and a corresponding decrease of collagen synthesis. This is the main pathophysiological mechanism leading to the disturbance of normal tissue regeneration and formation of chronic wounds / trophic ulcers (1,2).…”

Section: Physiological and Metabolic Disturbances In Patients With Chmentioning

confidence: 99%

“…The pathophysiology of diabetic foot syndrome (DFS) includes many mutually potentiating components, such as neuropathies, vascular disorders, impaired immunity, and infections, creating a vicious cycle (1)(2)(3). Numerous studies have been dedicated to the treatment of patients with chronic wounds, which has helped to work out recommendations for evidence-based approaches that are now recognized by the world community (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.

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Section: Physiological and Metabolic Disturbances In Patients With Chmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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Cardiovascular Pathology in Acute Stroke (Issues on Prevalence, Prevention and Treatment)

Румянцева

Оганов

Silina

et al. 2014

Cardiovasc Ther Prev

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The article concerns on the problems of vascular comorbidity epidemiology and pathophysiological aspects of heart disease, which became a leading etiopathologic factor of cerebral infarctions and hemorrhages. The relationship between coronary artery disease (CAD), atrial fibrillation, hypertension and cerebral infarction types is emphasized.Aim. To analyze the role of comorbidity, attributable to cardio-vascular pathology in the initiation, course, clinical features and outcomes of cerebral infarction.Material and methods. We performed a prospective study, including 1072 patients with stroke, attributable to various cardiovascular pathology, evaluated the influence of vascular comorbidity of variable degree on the course and outcomes at an inpatient stage and at follow-up.Results. We demonstrated a negative influence of CAD, atrial fibrillation and postinfarction cardiosclerosis on the incidence of cerebral infarction, unfavorable course of the disease and functional outcomes at inpatient stage. The combination of vascular comorbidity resulted in an increased mortality in post-stroke period during 6 years of follow-up.Conclusion. Epidemiology of vascular comorbidity, its role in cerebrovascular accidents in patients with cardiac pathology justifies the need of active realization of contemporary multidisciplinary prevention programs, prolonged instrumental monitoring and implementation of energy deficiency correction therapy in comprehensive treatment programs.

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Efficacy and safety of collagen biomaterial local application in complex treatment of the diabetic foot syndrome (final results of the multicenter randomised study)

Stupin

Silina

Gorskij

et al. 2018

Khir. Z. im. N.I. Pirogova

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Problems and Prospects of Intermediary Metabolism Correction in Patients With Vascular Comorbidity

Cited by 4 publications

References 3 publications

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Cardiovascular Pathology in Acute Stroke (Issues on Prevalence, Prevention and Treatment)

Efficacy and safety of collagen biomaterial local application in complex treatment of the diabetic foot syndrome (final results of the multicenter randomised study)

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