The analysis of industrial injuries when working at heights is conducted. Statistics show that a fall from a height takes more than 30% of the total number of accidents. Operations with the help of ladders are the most common type of works at heights. However, the ease of installation and use of ladders often leads to the fact that the persons performing the work do not pay enough attention to safety. The aim of the work was to improve the safety in operation at heights with the use of ladders inclined to the horizontal surface. An important prerequisite for the safe use of ladders is to ensure their stability. There were analyzed the most common devices used to increase the stability of ladders. The issue of applying a lifeline system attached to a ladder (if the ladder is affixed to a building or other structure), when working with a ladder at heights of more than 1.8 m, is considered. The inferiority of this issue is shown in the current regulatory documents. It was proposed to revise the relevant requirements in the regulatory documents on the possibility of using a lifeline system attached to the ladder, requirements for the durability of the ladders and methods of their testing.