Procalcitonin—a sepsis parameter in severe burn injuries

Heimburg, Dennis von; Stieghorst, W; Khorram-Sefat, Ramin; Pallua, Norbert

doi:10.1016/s0305-4179(98)00109-0

Cited by 109 publications

(58 citation statements)

References 17 publications

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“…According to the Carsin et al [24] serum PCT levels were increased during the fi rst hours following burn and rapidly stabilised and they concluded that PCT was a useful marker for determination of the course of patients with burns following burn. But, other investigators suggested that PCT may be a useful marker for the diagnosis of severe infectious complications after burn [17,20,22,25,26]. Our results were in concordance with the results of Lavrentieva et al [19] and Barati et al [13].…”

Section: Discussionsupporting

confidence: 93%

“…The method specifi c to the PCT molecule uses two separate monoclonal antibodies binding to the calcitonin and catacalcin regions. The minimum value detected by this method was 0.1 ng/mL and the measuring range was 0.1-500 ng/mL, while the pathological limit was >0.5 ng/mL [13,17]. A commercial ELISA kit (Neopterin ELISA, DRG Instruments GmbH, Berlin, Germany) was used according to the manufacturer's instructions to quantitatively determine the serum neopterin levels.…”

Section: Laboratory Testsmentioning

confidence: 99%

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Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Pilancı¹,

Erǧin²,

Sirekbasan³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0-12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the fi rst, the seventh, the fourteenth and the 21 st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classifi ed as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no signifi cant difference were present. Also, PCT and neopterin levels within the fi rst 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period.

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Section: Discussionsupporting

confidence: 93%

Section: Laboratory Testsmentioning

confidence: 99%

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Pilancı¹,

Erǧin²,

Sirekbasan³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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“…Unfortunately, a variety of unrelated factors, including severe systemic inflammation, organ dysfunction, tissue trauma, and many other aetiologies, have been shown to induce PCT release (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Evaluation of Neutrophil CD64 Expression and Procalcitonin as Useful Markers in Early Diagnosis of Sepsis

Cardelli

Ferraironi

Amodeo

et al. 2008

Int J Immunopathol Pharmacol

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Quantitation of neutrophil CD64 expression and procalcitonin (PCT) levels in blood samples have been recently proposed as useful tools for early detection of sepsis. To determine the usefulness of these tests, we analyzed blood samples of 112 patients, admitted to an intensive care unit (ICU), presenting clinical symptoms of sepsis, as well as of 50 healthy controls. At the end of the study, a retrospective analysis showed that only 52 ofthe 112 ICU-patients presented a real sepsis (positive blood culture). The results obtained indicated that of the 52 patients with sepsis, 50 and 49 presented levels of neutrophil CD64 expression~2398 molecules per cell (cut-off determined by receiver operator characteristic analysis) and PCT levels> 0.5 ng/ml (cut-off suggested by the manufacturer), respectively. However, the neutrophil CD64 test showed higher specificity in detecting sepsis since 5 out of the 60 ICU-patients without sepsis (negative blood culture), presented CD64 expression levels~2398 molecules per cell, PCT levels~0.5 ng/ml were shown in 27 patients. Moreover, while none of the 50 healthy controls presented a neutrophil CD64 level higher than the cut-off value, 5 patients presented PCT levels~0.5 ng/ml. In conclusion, our data seem to indicate that the quantitation of CD64 expression could be taken into consideration as a sensitive and specific test for early diagnosis of sepsis.

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“…To this date, no laboratory test has proven to be reliable enough to distinguish between an inflammatory response typical of a burn wound and sepsis. 12 In a study conducted by Lobo, et al, 13 it was established that severe patients who have high levels of CRP at the time of admission to the intensive care unit required a prolonged stay and had a higher mortality rate. Those patients whose CRP continued elevated at 48 hours had a significantly higher mortality than those whose levels reduced.…”

Section: Discussionmentioning

confidence: 99%

Assessment of C-reactive protein and procalcitonin levels to predict infection and mortality in burn children

2015

Arch Argent Pediat

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C-reactive protein (CRP) and procalcitonin (PCT) levels may distinguish between a systemic inflammatory response and an infection in burn children. Objectives. To establish the operative capability of CRP and PCT to diagnose infections and mortality. Methods. Burn patients admitted to the hospital with clinical suspicion of an infection were included. CRP and PCT were measured and their operative diagnostic capabilities were calculated. Results. Forty-eight patients (p) were included. Their median age was 49 months old (r: 17-86). The median burned surface area was 40% (r: 30-48%); 28 p (58%) had type AB and type B burn wounds. Infection was confirmed in 32 p (66.7%); the most common infection was burn-related sepsis (24 p, 75%), followed by burn wound infection (6 p, 19%). Eight patients (17%) died. It was not possible to establish CRP sensitivity and specificity because it was high in all patients, regardless of mortality, survival or the presence of infection. In relation to infections, PCT had a 90.6% sensitivity (95% confidence interval [CI]: 75.8-96.8%), a 18.8% specificity (95% CI: 6.6-43%), a 69% positive predictive value (PPV) and a 50% negative predictive value (NPV). In relation to 30-day mortality, sensitivity was 100% (95% CI: 67.6-100%), specificity 15% (95% CI: 7.1-29.1%), PPV 19% (95% CI: 10-33.3%) and NPV 100% (95% CI: 61-100%). Conclusions. In pediatric burn patients, neither CRP nor PCT showed an adequate operative capability to detect an infection or a fatal outcome.

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Procalcitonin—a sepsis parameter in severe burn injuries

Cited by 109 publications

References 17 publications

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Evaluation of Neutrophil CD64 Expression and Procalcitonin as Useful Markers in Early Diagnosis of Sepsis

Assessment of C-reactive protein and procalcitonin levels to predict infection and mortality in burn children

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