Procalcitonin levels differences in preeclampsia and non preeclampsia

Abstract

One of the main complications that cause maternal death is preeclampsia/eclampsia. Activation of the systemic inflammatory response is thought to play a role in the pathogenesis of preeclampsia. Urinary tract infections (UTI) can cause activation of the systemic inflammatory response, so that it is considered capable of causing preeclampsia. Procalcitonin is known as a marker of infection and very stable in serum, so it is a promising biomarker in detecting UTI. The investigators intend to investigate the association between UTI and preeclampsia through exploration of procalcitonin levels in preeclampsia and non-preeclampsia mothers. This study was a cross-sectional method, accident sampling technique. Respondents in this study amounted to 65, preeclampsia criteria were 40, and not preeclampsia were 25. The results showed no relationship between urinary tract infections during pregnancy and preeclampsia P = 0.074. Even so, procalcitonin levels in preeclampsia mothers were found to be higher than mothers without preeclampsia, with a value of P = 0.005. Which means that the inflammation that occurs in preeclampsia mothers is not caused by urinary tract infections. It is hoped that further research can be carried out on the relationship of urinary tract infections and preeclampsia by using a larger sample.

Influence of infectious factors on changes in hormonal indicators in women in the early period of miscarriage

“…In addition, in women of group 1 with a normal pregnancy, there was a significant increase in this indicator by 6 and even more at 12 weeks of pregnancy in relation to the results before pregnancy of the same group. At the same time, in women of group 2 with miscarriages and infections of the genitourinary system, there was an unreliable decrease in progesterone at 6 weeks and a significant decrease at 12 weeks of gestation in relation to the results before pregnancy (Fatimah et al, 2021;Vocroix, 2021). Nevertheless, the indicators of progesterone in women of group 2 at 6 and 12 weeks of pregnancy were significantly and reliably lower than those of women in group 1.…”

Prolonged newborns and prolong pregnancy

“…Changes observed in the placenta in overdue pregnancy are secondary, but in the future, they may play an important role in steroidogenesis, fetal status, and fetal activity. With a delayed pregnancy, the balance in a woman's hormonal and humoral systems is disturbed, which affects the formation of fertility dominants and the timely onset of labor Fatimah et al, 2021).…”