Procedure Guideline for Brain Perfusion SPECT Using 99mTc Radiopharmaceuticals 3.0

Juni, Jack E.; Waxman, Alan D.; Devous, Michael D.; Tikofsky, Ronald S.; Ichise, Masanori; Heertum, Ronald L. Van; Carretta, Robert F.; Chen, Charles C.

doi:10.2967/jnmt.109.067850

Cited by 99 publications

(80 citation statements)

References 3 publications

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“…It does so by mapping the blood flow distribution in both cortical and subcortical gray matter areas of the brain. The results are displayed in a two-dimension (2D) and three-dimension (3D) color rendition of relative perfusion maps as well as in a black and white volumetric rendition thresholded at the 65% level [23][24][25][26]. Results from this assessment revealed extensive bilateral hypoperfusion most accentuated in the frontal and temporal lobes (see the upper row of Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

Best¹,

Pavel²

2016

J Neurol Neurosci

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Background: This is the first case report of a stepped novel anti-inflammatory treatment plan for a complicated, markedly disabling neuropsychiatric condition with multiple comorbidities. The treatment consisted of 1) hyperbaric oxygen therapy, 2) combination therapy of infused ketamine applied concurrent with transcranial magnetic stimulation, 3) administration of perispinal etanercept, and finally 4) non-invasive transnasal Sphenopalatine Ganglion block.

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Section: Resultsmentioning

confidence: 99%

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

Best¹,

Pavel²

2016

J Neurol Neurosci

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“…241,261 The AAN's last evaluation of the body of literature occurred in 1996. 260 However, the body of research and expert review since that time suggest a re-evaluation may change SPECT's overall accepted utility in TBI.…”

Section: Discussionmentioning

confidence: 99%

“…240 As nuclear medicine continues to progress through the era of molecular imaging, numerous novel radiopharmaceuticals currently in development or being used for research purposes may be available clinically in the near future. 241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma. 242 As nuclear medicine continues to progress through the era of molecular imaging, numerous novel radiopharmaceuticals currently in development or being used for research purposes may be 241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma.…”

Section: Single Photon Emission Computed Tomographymentioning

confidence: 99%

“…241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma. 242 As nuclear medicine continues to progress through the era of molecular imaging, numerous novel radiopharmaceuticals currently in development or being used for research purposes may be 241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma. 242 Nuclear medicine brain SPECT potential for TBI neuroimaging TBI may encompass a multitude of pathological findings, and clinical presentation, such as post-concussive syndrome, may represent an overlap of other concurrent disease processes or preexisting processes.…”

Section: Single Photon Emission Computed Tomographymentioning

confidence: 99%

“…Although professional societies such as the ACR and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) have published imaging guidelines, a specific standardized approach for all researchers to implement nuclear medicine SPECT for TBI imaging does not exist. 235,258,259 Other limitations noted include significant variability in the time frame in which imaging takes place after TBI, selection of objective testing to be universally used in research to confirm clinical data with imaging, an accounting of medication/psychiatric diagnoses and other compounding factors, and lack of a standardized way to quantify TBI image findings.…”

Section: Single Photon Emission Computed Tomographymentioning

confidence: 99%

See 2 more Smart Citations

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

Amyot

Arciniegas

et al. 2015

Journal of Neurotrauma

183

147

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The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI.

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rCBF SPECT for detection of frontotemporal dementia in people with suspected dementia

Coulthard

Archer

Smailagic

et al. 2013

Cochrane Database of Systematic Reviews

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Procedure Guideline for Brain Perfusion SPECT Using 99mTc Radiopharmaceuticals 3.0

Cited by 99 publications

References 3 publications

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

rCBF SPECT for detection of frontotemporal dementia in people with suspected dementia

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