Proceedings: Bone mineral determinations on long-term diabetics

Ringe, J. D.; Kuhlencordt, F.; Kruse, H.‐P.

doi:10.2214/ajr.126.6.1300

Cited by 39 publications

(4 citation statements)

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“…In this cross-sectional study of bone mass in adult diabetic patients, we confirm the results of previous studies (1)(2)(3)(4)(5)(6)(7)20) that IDDM patients, men and women, have a decreased mean bone mass at the peripheral skeleton compared with age-matched controls despite a considerable overlap of in- in Caucasian women than men. The deficit in bone mass was not confined to a few patients, because 11 and 12 of 14 female patients had a BMC below the normal average at the radius (3 cm) or lumbar spine, respectively (Fig.…”

Section: Discussionsupporting

confidence: 89%

Mineral Metabolism and Bone Mass at Peripheral and Axial Skeleton in Diabetes Mellitus

Auwerx

Dequeker²,

Bouillon³

et al. 1988

Diabetes

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Bone mineral content (BMC), mineral homeostasis, and diabetes control were evaluated in 31 Caucasian insulin-dependent diabetic patients (disease duration 18.3 +/- 7.7 yr, mean +/- SD) with normal kidney function. To evaluate bone mass, we performed radiogrammetry and single- and dual-photon absorptiometry. In women, a significantly lower mean BMC was found in the distal radius, at a mixed trabecular-cortical (P less than .01) and a cortical (P less than .05) site, as well as in the lumbar spine (P less than .02). In diabetic men, mean BMC was significantly reduced at the trabecularcortical (P less than .01) and cortical (P less than .05) sites of the radius but not in the lumbar spine. When expressed as densities (i.e., BMC/width or lumbar BMC/area), only the BMC/width at the radius cortical area was significantly reduced in women (P less than .05). The results of the radiogrammetry showed a larger endosteal diameter in the diabetic women, resulting in a significantly lower cortical thickness (P less than .05). Diabetic men did not show abnormalities on radiogrammetry. Diabetic patients had diminished serum calcium and phosphorus concentrations (P less than .001), whereas serum parathyroid, 25-hydroxyvitamin D3, and concentrations of both total and free 1,25-dihydroxyvitamin D3 were normal. No correlation between parameters of diabetes control (HbA1, insulin dose, and triglycerides) or calcium-regulating hormones and BMC were found. These data confirm that, despite large overlap of individual values, mean bone mass at the peripheral skeleton is significantly decreased in diabetic patients. Moreover, we report that the BMC of the lumbar spine is significantly reduced in female diabetic patients.

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Section: Discussionsupporting

confidence: 89%

Mineral Metabolism and Bone Mass at Peripheral and Axial Skeleton in Diabetes Mellitus

Auwerx

Dequeker²,

Bouillon³

et al. 1988

Diabetes

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“…Reduced bone mass has been reported in young patients with insulin-dependent diabetes mellitus (Frazer et al, 198 1;Hough, 1987;Hui et al, 1985;Leon el al., 1989;Levin et al, 1976;McNair et al, 1979;Meema & Meema, 1967;Roe et al, 1991;Rosenbloom et al, 1977;Santiago et al, 1977;Shore et al, 1981;Wiske et al, 1982); in adult patients, similar findings have been reported (Auwerx et al, 1988;Giacca et al, 1988;Johnston et al, 1985;Levin et al, 1976;McNair et al, 1981;Ringe et al, 1976). The reductions in bone mass reported in these studies have generally been small and their clinical significance, in terms of fracture risk, has not been established (Bouillon, 1991).…”

mentioning

confidence: 56%

“…These results demonstrate significant reductions in whole body bone mineral content and femoral bone density in middle-aged women with insulin-dependent diabetes mellitus; however, values for whole body and lumbar spine bone density were similar in the two groups. Previous studies in adult patients with insulin-dependent diabetes have documented reductions in bone mass, mainly in the metacarpals and radius (Auwerx et al, 1988;Johnston et al, 1985;Levin et al, 1976;McNair et al, 1981;Ringe et al, 1976). Some case control studies of osteoporotic fracture have reported an increase in relative risk for diabetics (Alffram, 1964;Paganini-Hill et al, 1981;Weintroub et al, 1980) but this finding has not been universal and in one large study fracture risk was decreased (Heath et al, 1980).…”

Section: Discussionmentioning

confidence: 97%

Whole body composition and regional bone mass in women with insulin‐dependent diabetes mellitus

Compston

Smith

Matthews

et al. 1994

Clinical Endocrinology

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“…The mechanism for the lower bone SOS in LGA infants is not clear. When maternal diabetes coexists, decreased maternal mineral stores, 12,13 and decreased placental mineral transport 14 have been suggested as contributing factors. The very perturbed maternal -fetal environment in diabetes may be influential by many other potential mechanisms.…”

Section: Littner Et Almentioning

confidence: 99%

Decreased Bone Ultrasound Velocity in Large-for-Gestational-Age Infants

et al. 2003

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BACKGROUND:Bone speed of sound is a measure of bone breakability. There are few reports on bone mineral content in large for gestational age infants; most of them in infants of diabetic mothers. There are no data on bone speed of sound in large for gestational age infants of nondiabetic mothers. OBJECTIVE:To test the hypothesis that large for gestational age infants of nondiabetic mothers have lower bone speed of sound than appropriate for gestational age infants. DESIGN/METHODS:Bone speed of sound was measured within the first 96 hours of life at the right tibial midshaft in 25 singleton large for gestational age infants of non diabetic mothers and compared to appropriate for gestational age controls. RESULTS:Bone speed of sound measured in large for gestational age infants of nondiabetic mothers was lower than in controls.CONCLUSIONS: Large for gestational age infants of nondiabetic mothers have lower bone speed of sound than controls.

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Proceedings: Bone mineral determinations on long-term diabetics

Cited by 39 publications

References 0 publications

Mineral Metabolism and Bone Mass at Peripheral and Axial Skeleton in Diabetes Mellitus

Mineral Metabolism and Bone Mass at Peripheral and Axial Skeleton in Diabetes Mellitus

Whole body composition and regional bone mass in women with insulin‐dependent diabetes mellitus

Decreased Bone Ultrasound Velocity in Large-for-Gestational-Age Infants

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