Proceedings from the 2022 Consensus Conference to Implement Optimal Venous Thromboembolism Prophylaxis in Trauma

Abstract

On May 4 and 5, 2022, a meeting of multidisciplinary stakeholders in the prevention and treatment of venous thromboembolism (VTE) after trauma was convened by the Coalition for National Trauma Research, funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health, and hosted by the American College of Surgeons in Chicago, Illinois. This consensus conference gathered more than 40 in-person and 80 virtual attendees, including trauma surgeons, other physicians, thrombosis experts, nurses, pharmacists, researchers, and patient advocates. The objectives of the meeting were twofold: (1) to review and summarize the present state of the scientific evidence regarding VTE prevention strategies in injured patients and (2) to develop consensus on future priorities in VTE prevention implementation and research gaps. To achieve these objectives, the first part of the conference consisted of talks from physician leaders, researchers, clinical champions, and patient advocates to summarize the current state of knowledge of VTE pathogenesis and prevention in patients with major injury. Video recordings of all talks and accompanying slides are freely available on the conference website (https://www.nattrauma.org/research/research-policies-templatesguidelines/vte-conference/). Following this curriculum, the second part of the conference consisted of a series of small-group breakout sessions on topics potentially requiring future study. Through this process, research priorities were identified, and plans of action to develop and undertake future studies were defined. The 2022 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma answered the National Trauma Research Action Plan call to define a course for future research into preventing thromboembolism after trauma. A multidisciplinary group of clinical champions, physicians, scientists, and patients delineated clear objectives for future investigation to address important, persistent key knowledge gaps. The series of papers from the conference outlines the consensus based on the current literature and a roadmap for research to answer these unanswered questions.

Survey of venous thromboembolism prophylaxis in trauma patients: current prescribing practices and concordance with clinical practice guidelines

“…Recommendations for VTE chemoprophylaxis span multiple specialties (neurosurgery, orthopedics, ACS) and efforts need to be focused on aligning practice recommendations among surgical specialties. To promote this goal, a National Institutes of Health sponsored conference titled ‘2022 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma’ was held in May 2022 with the initial aim of bringing together a multidisciplinary cohort of trauma experts to review the current state of the science, identify gaps in the literature, and prioritize a future research agenda 16–18 21 24…”

Timing of venous thromboembolism prophylaxis initiation after injury: Findings from the consensus conference to implement optimal VTE prophylaxis in trauma

“…Further research, particularly prospective multicenter clinical trials, is needed to more completely delineate the optimal time for VTEp initiation after solid organ, TBI, and spine injuries. 46…”

Novel therapeutic medications for venous thromboembolism prevention in trauma patients: Findings from the Consensus Conference to Implement Optimal Venous Thromboembolism Prophylaxis in Trauma

“…The 2022 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma was convened to define evidence-based guidelines and to address gaps in clinical care and research related to VTE 3 . One of the defined goals of this conference was to discuss novel approaches to postinjury VTE prophylaxis that could potentially improve patient compliance and further decrease VTE risk.…”