Process Intensification and Industry 4.0: Mutually Enabling Trends

Bisschops, Marc; Cameron, Loe

doi:10.1002/9783527827343.ch7

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditional bioreactors suffer from the long installation times as well as the resulting rigidity in operation (Bisschops & Cameron, 2021). Single‐use bioreactor systems (SUBs) are being increasingly used for mass‐scale production (BioPlan Associates, 2019).…”

Section: State Of the Art And Future Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Advances in bioreactor control for production of biotherapeutic products

Nikita

Mishra

Gupta

et al. 2023

Biotech & Bioengineering

View full text Add to dashboard Cite

Advanced control strategies are well established in chemical, pharmaceutical, and food processing industries. Over the past decade, the application of these strategies is being explored for control of bioreactors for manufacturing of biotherapeutics.Most of the industrial bioreactor control strategies apply classical control techniques, with the control system designed for the facility at hand. However, with the recent progress in sensors, machinery, and industrial internet of things, and advancements in deeper understanding of the biological processes, coupled with the requirement of flexible production, the need to develop a robust and advanced process control system that can ease process intensification has emerged. This has further fuelled the development of advanced monitoring approaches, modeling techniques, process analytical technologies, and soft sensors. It is seen that proper application of these concepts can significantly improve bioreactor process performance, productivity, and reproducibility. This review is on the recent advancements in bioreactor control and its related aspects along with the associated challenges. This study also offers an insight into the future prospects for development of control strategies that can be designed for industrial-scale production of biotherapeutic products.

show abstract

Section: State Of the Art And Future Perspectivementioning

confidence: 99%

“…Single-use bioreactor: pushing the boundaries of biologics manufacturing Traditional bioreactors suffer from the long installation times as well as the resulting rigidity in operation (Bisschops & Cameron, 2021).…”

Section: Advancements In Bioreactor Control With Process Analytical T...mentioning

confidence: 99%

Advances in bioreactor control for production of biotherapeutic products

Nikita

Mishra

Gupta

et al. 2023

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

Comparing in silico flowsheet optimization strategies in biopharmaceutical downstream processes

Keulen,

Apostolidi,

Geldhof

et al. 2024

Biotechnology Progress

View full text Add to dashboard Cite

The challenging task of designing biopharmaceutical downstream processes is initially to select the type of unit operations, followed by optimizing their operating conditions. For complex flowsheet optimizations, the strategy becomes crucial in terms of duration and outcome. In this study, we compared three optimization strategies, namely, simultaneous, top‐to‐bottom, and superstructure decomposition. Moreover, all strategies were evaluated by either using chromatographic Mechanistic Models (MMs) or Artificial Neural Networks (ANNs). An overall evaluation of 39 flowsheets was performed, including a buffer‐exchange step between the chromatography operations. All strategies identified orthogonal structures to be optimal, and the weighted overall performance values were generally consistent between the MMs and ANNs. In terms of time‐efficiency, the decomposition method with MMs stands out when utilizing multiple cores on a multiprocessing system for simulations. This study analyses the influence of different optimization strategies on flowsheet optimization and advices on suitable strategies and modeling techniques for specific scenarios.

show abstract

Process Intensification and Industry 4.0: Mutually Enabling Trends

Cited by 2 publications

References 14 publications

Advances in bioreactor control for production of biotherapeutic products

Advances in bioreactor control for production of biotherapeutic products

Comparing in silico flowsheet optimization strategies in biopharmaceutical downstream processes

Contact Info

Product

Resources

About