Process Intensification for Production and Recovery of Biological Products

Abstract

Bioprocesses are important biological reactions which need several sophisticated methods and equipment to produce many novel and important compounds which some of them are traditionally produced by synthetic chemical reactions. In bioprocesses, the products are often produced in a dilute environment and finally they require a high purity. Because of that, downstream processes are usually included a large number of separation steps. Size and capital costs of the equipment are two main limitations of using bioprocesses at industrial scale. Bioprocess intensification by minimizing, substitution, moderation and simplification of the methods and equipment, drastically leads to sustainable processes. This study looks at intensification of the emerging equipment and operational methods and their advantages to lead smaller and cleaner bioprocess plants which in turn, increases production efficiency and quality and decreases byproducts formation, capital cost and energy consumption.

Bioconcrete: next generation of self-healing concrete

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Synthesis and Application of Amine Functionalized Iron Oxide Nanoparticles on Menaquinone-7 Fermentation: A Step towards Process Intensification

“…Process intensification as a method for decreasing the process steps can be a promising approach. These reductions can come from decreasing the size of individual equipment or from removing the number of involved unit operations [ 4 ]. Process integration, such as in-situ cell recovery, has introduced as a valuable tool to reduce the operation units and increase the yield of process.…”

Amino acids production focusing on fermentation technologies – A review

“…PI is defined as any technological development that lead to a safer, cleaner and more energy efficient process (Babi et al, 2016). In this field two different approaches can be followed: intensification of the equipment such as new reactors, heat exchangers or mass transfer units, or intensification of the process itself using innovative separations strategies or techniques (Vaghari et al, 2015). For example, changing the reactor configuration (operation mode) to repeated batch or fed-batch reactors, may lead to a lysine productivity that is twice that of the batch (Ikeda, 2003).…”