Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

Khan, Daulat Haleem; Bashir, Sajid; Figueiredo, Patrícia; Santos, Hélder A.; Khan, Muhammad Imran; Peltonen, Leena

doi:10.1016/j.jddst.2019.01.012

Cited by 58 publications

(27 citation statements)

References 36 publications

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“…Nonetheless, the C=C stretching (at 1674 cm −1 ) zenith of the cholesterol faded, validating the cholesterol enclosure in the lipid bilayer [45]. Further, the prominent peaks of the drug molecule (E. angustifolia) were also absent in the niosomes' structures, which were observed by others as well [8,38].…”

Section: Fourier Transform Infrared (Ftir) Analysismentioning

confidence: 66%

“…Many researchers have explored these colloidal emulsions in novel drug delivery systems for the therapeutic applications due to their excellent specification, such as insolubility, biocompatibility, and capability to carry both hydrophilic and hydrophobic drugs [5,6]. The content of surfactants and lipids can be altered to optimize the formulation size and the drug encapsulation efficiency to achieve high desired activity for each drug [7,8]. Various drugs have been formulated in the form of niosomes.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation

et al. 2021

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With the increased occurrence of antibiotic-resistant bacteria, alternatives to classical antibiotics are urgently needed for treatment of various infectious diseases. Medicinal plant extracts are among the promising candidates due to their bioactive components. The aim of this study was to prepare niosome-encapsulated Echinacea angustifolia extract and study its efficacy against multidrug-resistant Klebsiella pneumoniae strains. Encapsulation was first optimized by Design of Experiments, followed by the empirical study. The obtained niosomes were further characterized for the size and morphology using dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Spherical niosomes had a diameter of 142.3 ± 5.1 nm, as measured by DLS. The entrapment efficiency (EE%) of E. angustifolia extract reached up to 77.1% ± 0.3%. The prepared niosomes showed a controlled drug release within the tested 72 h and a storage stability of at least 2 months at both 4 and 25 °C. The encapsulated E. angustifolia displayed up to 16-fold higher antibacterial activity against multidrug-resistant K.pneumoniae strains, compared to the free extract. Additionally, the niosome exhibited negligible cytotoxicity against human foreskin fibroblasts. We anticipate that the results presented herein could contribute to the preparation of other plant extracts with improved stability and antibacterial activity, and will help reduce the overuse of antibiotics by controlled release of natural-derived drugs.

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Section: Fourier Transform Infrared (Ftir) Analysismentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation

et al. 2021

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“…However, the N1S3 biolubricant displays weaker intensity of the peak of the O-H group than the N1S2 sample. This is probably a result of an excessive amount of surfactant which is more hydrophobic than NDCt [37].…”

Section: Resultsmentioning

confidence: 99%

Stability, Viscosity, and Tribology Properties of Polyol Ester Oil-Based Biolubricant Filled with TEMPO-Oxidized Bacterial Cellulose Nanofiber

Rahmadiawan

Abral

Nasruddin

et al. 2021

International Journal of Polymer Science

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This research is aimed at studying the stability and tribology properties of the polyol ester oil- (POE-) based biolubricant mixed with various filler loadings from microparticle of TEMPO-oxidized bacterial cellulose (NDCt) as an additive and sorbitan monostearate (Span 60) as a surfactant. Morphology, rheology, and tribology tests were conducted. The addition of NDCt and Span 60 to pure POE as a base fluid showed elevated viscosity, lower value of coefficient friction (COF), and a remarkable decrease in the wear rate (WR). The presence of 0.6 wt% NDCt and 1.8 wt% Span 60 in POE (N2S4) decreased the COF value by 79% in comparison to POE. At room temperature, this N2S4 biolubricant sample showed a higher thermal conductivity by 4% and lower WR value by 49% compared to POE. This study introduced the preparation of the ecofriendly biolubricant filled with NDCt improving the tribology properties remarkably.

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“…Twenty scans were recorded for each spectrum. Smoothing was done where necessary to reduce the noise without loss of any peak [17].…”

Section: Fourier-transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…Five milligrams of the scaffolds was taken into aluminum pans and was then hermetically sealed. A controlled heating and cooling rate was maintained at 10°C/min in nitrogen atmosphere [17]. The tensile or mechanical strength of the nanofibrous scaffolds were measured using a universal testing machine.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

Ilomuanya

Okafor

Amajuoyi

et al. 2020

Beni-Suef Univ J Basic Appl Sci

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Background: In this study, the chronic wound healing ability of PLA-based electrospun nanofibers loaded with hyaluronic acid, valsartan, and ascorbic acid is explored. PLA-based scaffolds were fabricated by electrospinning, followed by loading the scaffolds with different concentrations of hyaluronic acid, valsartan, and ascorbic acid hydrogels. The produced formulations were characterized by scanning electron microscopy imaging (SEM), tensile strength testing, Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). An in vitro drug release study was conducted to monitor the release of valsartan from the different formulations. This was followed by exploring the wound healing effects of the scaffolds in alloxan-induced diabetic rats and comparing the wound healing effects with positive and negative controls. Results: The average diameter of the fibers was in the range of 300 to 490 nm with high porosity in the range of 63.90 to 79.44%, offering a large surface area-to-volume ratio, enhanced drug solubility, oxygen permeability, and fluid uptake. The presence of valsartan significantly impacted on the re-epithelization rate. Percentage reepithelization rate was 31.2% ± 1.77% in the absence of treatment. Histologic section of tissue showed skin with underlying loose fibro-collagenous stroma (dermis) containing sebaceous glands and hair follicles for animals treated with VA, VB, VC, and VD. All the scaffolds reduced the number of inflammatory cell infiltrates at the wound site compared to the no treatment and conventionally treated groups. Conventional antibiotic treatment and VD (electrospun biomimetic scaffolds containing ascorbic acid) had % re-epithelization rates of 59.45% ± 1.69% and 62.01% ± 1.68% which were significantly lower than the PLA/HA-valsartan hydrogel scaffolds with VB having the highest % re-epithelization rate of 85.5% ± 1.7% (Figure 4B & 5C). Conclusion: This study explored the use of biomimetic polylactic acid-based electrospun fiber and HA-valsartan hydrogel scaffold incorporating topical angiotensin receptor blockers to successfully accelerate wound healing. The novel PLA-based electrospun fibers loaded with hyaluronic acid-valsartan hydrogels were stable and possessed proven diabetic wound healing property. This was as a result of the known biomimetic effect of the fibers and increased re-epithelization facilitated by the hydrogels containing valsartan.

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Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

Cited by 58 publications

References 36 publications

Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation

Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation

Stability, Viscosity, and Tribology Properties of Polyol Ester Oil-Based Biolubricant Filled with TEMPO-Oxidized Bacterial Cellulose Nanofiber

Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

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