Processed tomatoes improves the antioxidant status of carbon tetrachloride-intoxicated rat tissues

Pinto, Carmen; Rodríguez-Galdón, Beatriz; Cestero, Juan J.; Macı́as, Pedro

doi:10.1007/s00217-018-3097-1

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…LP cannot be synthesized in the human body and can only be obtained through diet, which has various health benefits and no harmful effects have been found in high doses [ 18 ]. Therefore, researchers are increasingly interested in the physiological functions of LP, which are antioxidant, anti-inflammatory, immunomodulatory, anticancer, and antitumor [ 19 , 20 ]. It is worth noting that the antioxidant capacity of LP is 100 times that of vitamin E, due to the conjugated double bond contained in the structure [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis

Xiao

Niu

et al. 2022

Nutrients

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Cyclophosphamide (CYC) is the first-line chemotherapy drug for cancer in clinical practice, and its intestinal toxicity seriously affects the treatment effect and prognosis of patients. Lycopene (LP) is the main pigment of ripe tomatoes and has strong antioxidant activity. However, the mechanism by which LP prevents CYC-induced intestinal injury remains unclear. The aim of this study was to investigate the mechanism of LP in preventing intestinal toxicity caused by CYC chemotherapy in mice. The results showed that LP significantly prevented spleen and thymus atrophy induced by CYC. In terms of intestinal injury, LP significantly increased the levels of superoxide dismutase (SOD), secretory immunoglobulin A (sIgA), interleukin (IL)-4, IL-12, and interferon (IFN)-γ, decreased the content of lipid oxidation (MDA), upregulated the protein expressions of toll-like receptors 4 (TLR4), myeloid differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), toll/IL-1receptor domain containing adaptor protein inducing IFN-β (TRIF), p-P38 MAPK (P38), and p- nuclear factor kappa-B (NF-κB) p65, and improved the small intestine tissue injury induced by CYC. In terms of liver injury, LP significantly increased the content of glutathione (GSH), decreased the contents of MDA, nitric oxide (NO), IL-1β, IL-6, and tumor necrosis factor (TNF)-α, and repaired the liver tissue injury induced by CYC. Importantly, 10 mg/kg LP significantly prevented intestinal microbiota dysregulation in CYC mice. These results suggested that LP significantly prevented intestinal injury induced by CYC in mice by regulating the TLR4-MyD88/TRIF-TRAF6 signaling pathway and gut-liver axis.

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Section: Introductionmentioning

confidence: 99%

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis

Xiao

Niu

et al. 2022

Nutrients

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“…Tomato fruits are an excellent natural supplement of minerals, essential nutrients, and many other secondary metabolites such as lycopene, carotene, vitamin C, and polyphenols [2,3]. Due to these valuable nutrients, utilization of tomatoes can decrease the risk of various fatal diseases such as cancer and coronary artery diseases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Profile, Nutritional Composition, Functional Properties, and Antioxidant Activity of Newly Grown Parthenocarpic and Normal Seeded Tomato

Dominic

Hussain

Chatha

et al. 2021

Journal of Chemistry

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The aim of the study was to compare the physicochemical parameters, sugar, vitamin C, and phenolic profiles in five genotypes of local indeterminate tunnel tomato hybrid (LITTH) (LITTH-778, LITTH-784, LITTH-786, LITTH-788, and LITTH-790) of natural parthenocarpic tomato (NPT) and normal seeded tomato (NST). Samples were collected from the experimental fields of Ayub Agricultural Research Institute, Faisalabad, Pakistan. Physical parameters (fruit shape, fruit weight, fruit length, fruit width, number of seeds per fruit, and shelf-life) and chemical composition (moisture, ash, crude fat, crude fiber, total carbohydrate, crude protein, and vitamin C) of NPT and NST were analyzed by reported methods. The methanolic extracts of tomato pulp were prepared by shaking and extracts were assayed for antioxidant activity. Sugar contents and phenolic profile of NPT and NST were estimated using HPLC method. Weight and size of NPT were less and smaller than the NST. Moreover, NPT were seedless with longer shelf-life and had more phenolic and flavonoid contents than the NST. HPLC analysis revealed that chlorogenic acid, gallic acid, and p-coumaric acid were major phenolics in methanol (polar solvent) extracts of NST, and caffeic acid, gallic acid, and p-coumaric acid in NPT extract. NPT contained higher concentration of sugar contents, but lower concentration of vitamin C than NST. In 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, NPT fruit extracts showed high scavenging activity with the 50% inhibitory concentration (IC50) value of 22.56 μg/mL compared to NST fruit extracts having IC50 29.49 μg/mL. This study provided useful information for farmers and nutritionists.

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Momordica cymbalaria improves reproductive parameters in alloxan-induced male diabetic rats

et al. 2021

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Processed tomatoes improves the antioxidant status of carbon tetrachloride-intoxicated rat tissues

Cited by 3 publications

References 49 publications

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis

Phenolic Profile, Nutritional Composition, Functional Properties, and Antioxidant Activity of Newly Grown Parthenocarpic and Normal Seeded Tomato

Momordica cymbalaria improves reproductive parameters in alloxan-induced male diabetic rats

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