Processing of hydroxyapatite via microemulsion and emulsion routes

Lim, Geok-Kieng; Wang, J.; Ng, S. C.; Chew, C. H.; Gan, L. M.

doi:10.1016/s0142-9612(97)00081-1

Cited by 155 publications

(81 citation statements)

References 15 publications

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“…The similar chemical structure to the inorganic component of bone * Corresponding author: huzaifah.usm@gmail.com matrix makes them a perfect candidate for nano drug and gene delivery system [13]. The potential of nanoscale HAp to kill and inhibit the spread of cancer cells determines their success and high performance as therapeutic agent carrier [14,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Yusoff

Salimi

Jamlos

2017

e-J. Surf. Sci. Nanotech.

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Magnetic transportation of therapeutic agents to the infected site in the body promises a superb platform for cancer treatment. To increase the safety profile and to stay clear from the agglomeration issue, core shell structure of magnetite-hydroxyapatite (Fe3O4-HAp) nanoparticles was developed. Fe3O4 as the core was synthesised by coprecipitation method which then coated with HAp layer through the sol-gel technique to maintain its high crystalline property. Optimum process parameters were applied during the fabrication process to yield small nanocomposites. The results show that HAp retained its phase purity and molecular structure even with the addition of Fe3O4 as analysed by XRD and FTIR. The FESEM and TEM micrographs show a magnificent monodispersed distribution of functionalised Fe3O4-HAp nanoparticles with the size of around 36 nm. EDXRF result confirmed the Ca/P ratio of 1.63, close to the value of main inorganic material of human bones (HAp) and possessed the superparamagnetic properties with saturation magnetisation of 23.274 emu/g as displayed by VSM curves. Thus, the dual affinity of the magnetic Fe3O4 and excellent biocompatibility HAp offer a synergetic effect as the drug or gene delivery vehicle to stealthy localize in infection site.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Yusoff

Salimi

Jamlos

2017

e-J. Surf. Sci. Nanotech.

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“…For example, smaller crystal size and more imperfect crystals, being subjected to dissolution (LeGeros 1988;Hurson et al 1993), may affect the extent of bone loss in osteoporosis and other metabolic diseases (Glenn 2008). These size-dependent properties of HA motivated researchers to adopt a wide-range of synthesis techniques, such as chemical precipitation (Puvvada et al 2010), hydrothermal processing (Luo and Nieh 1996), sol-gel (Shirkhanzadeh 1998), micro-emulsion processing (Earl et al 2006), wet chemical methods incorporating a freezedrying step (Bogdanoviciene et al 2006), and microwave irradiation (Lim et al 1997) to obtain HA nanoparticles with varied sizes and morphologies. The wet chemical process, based on precipitation route, is however the most convenient and commonly used process for the synthesis of nanocrystalline HA material.…”

Section: Introductionmentioning

confidence: 99%

Effect of temperature on morphology of triethanolamine-assisted synthesized hydroxyapatite nanoparticles

et al. 2012

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Hydroxyapatite (HA) nanoparticles have been synthesized using ortho-phosphoric acid as the source of PO 4 3-ions, and calcium chloride, suitably complexed with triethanolamine, as the calcium source. The effect of temperature on the morphology of the product has been investigated. The chemical compositions of the samples have been established through Fourier transform infrared spectroscopy. This study reveals that A-type and B-type carbonate substitution are present in HA samples and the concentration of carbonate ions decrease with rise in temperature. Morphological analyses by TEM studies suggest that the average lengths and widths of the needle-shaped particles size increases with temperature up to 50°C, while a morphological change of the particles from needle to spherical shape is observed on raising the temperature above 50°C. This change in morphology has been assigned to the apparent solubility of HA at these temperatures, which has been studied by the determination of thermochemical properties of the reaction system by endpoint conductivity and electrophoretic mobility measurements.

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“…This is further complicated by the fact that all mineralization processes are ultimately controlled by the cells directly associated to the tissue formation [8]. In literatures, nanometer scaled HAP powders and coatings can be synthesized using a number of strategies including sol-gel processing [9], co-precipitation [10,11], emulsion techniques [12], batch hydrothermal processes [13][14][15][16][17], mechano-chemical methods [18] and chemical vapor deposition [19]. However, bio-compatible and environment-friendly pathway to synthesize biocomposites of HAP-biomolecule is also being explored.…”

Section: Introductionmentioning

confidence: 99%

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

Li¹,

Zhao²,

Ding³

et al. 2011

Express Polym. Lett.

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Abstract. Biomimetic mineralization was performed on a large scale by a rapid and efficient approach. Chitosan scaffolds were placed in a mixed solution of urea, ethanol and distilled water, followed by the introduction of dibasic sodium phosphate (0.1M) and calcium chloride (0.1M) with the molar ratio of 1.67. These mixed solvents was then adjusted to weakly alkaline by adding sodium hydroxide solution. Finally the reaction mixture was sealed and kept at 80ºC for predetermined time. The composition and morphology of the apatite and the hybrid scaffolds were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) and environmental scanning electron microscopy (ESEM). The mechanism of nucleation and growth of crystals was discussed as well. The results revealed that chitosan scaffolds improved the crystallinity of hydroxyapatite (HAP) crystals. With the extension of mineralization time, the mineral layers on the outer surface and inner section of chitosan scaffolds increased as well. Furthermore, the compressive strength and modulus of the HAP-chitosan scaffolds biocomposites increased to 0.55±0.003 and 29.29±1.25 MPa respectively. Such one-pot approach may be extended to the mineralization of other materials and will have a broad application in the future.

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Processing of hydroxyapatite via microemulsion and emulsion routes

Cited by 155 publications

References 15 publications

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Effect of temperature on morphology of triethanolamine-assisted synthesized hydroxyapatite nanoparticles

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

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