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Khawly, Joseph A.; TX, Houston; McCuen, Brooks W.; NC, Durham

doi:10.1097/00006982-199803000-00027

Cited by 1 publication

(1 citation statement)

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“…All tested hydrogels, no matter how promising, may mimic the ascorbate system keeping the oxygen gradient within the vitreous chamber. For this reason and possibly for a long time still to come, the risk of OAG should be overtly discussed with patients especially because PPV indications since the very first cases from Machemer [ 50 ] have nowadays expanded to include less invalidating conditions such as vitreous floaters. The risk to benefit ratio for every single procedure will need careful consideration and thorough patients’ comprehension as Hippocrates himself thought us.…”

Section: Discussionmentioning

confidence: 99%

Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?

Rossi

Ripandelli

2020

JCM

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Purpose is to review the pathogenic mechanism for ocular hypertension and glaucoma development after pars plana vitrectomy. Both acute and chronic causes are considered, and special attention is paid to the theories and clinical evidence on the risk of developing Open Angle Glaucoma (OAG) after Pars Plana Vitrectomy (PPV). Most existing scientific literature on the issue agree on the role of ascorbate as an oxygen scavenger within the vitreous chamber. Oxygen tension in the vitreous and anterior chamber is maximum inn proximity of the retinal surface and endothelium, respectively and steeply decreases toward the lens, on both sides, and trabecular meshwork. Vitreous removal and, to a lesser extent, liquefaction, greatly reduces oxygen tension gradient in vitreous chamber while cataract extraction has similar effects on anterior chamber oxygen gradients. Oxygen derivatives originated from the cornea and retina are actively reduced by the vitreous gel and/or the crystalline lens. Vitreous removal and cataract extraction reduce drastically this function. Most reported clinical series confirm this hypothesis although protocol difference and follow-up length greatly impact the reliability of results.

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Section: Discussionmentioning

confidence: 99%