Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Marcet, Ismael; Weng, Shihan; Sáez‐Orviz, Sara; Rendueles, Manuel; Dı́az, Mario

doi:10.1016/j.jfoodeng.2018.06.030

Cited by 39 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The EE% was determined considering only the three major components of EOt and it corresponded to 52.81 ± 2.69% (Table II) for o-cymene, γ -terpinene, and thymol. These results are consistent with those of Marcet et al [47], who obtained thymol-loaded PLA NC with a mean size next to 260 nm and an EE of 60.3 ± 8%. In addition, they demonstrated that thymol-loaded PLA NC had improved antimicrobial properties in comparison with the non-encapsulated thymol.…”

Section: B Physicochemical Characterization Of Nc-eotsupporting

confidence: 93%

Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.)

Pina-Barrera

Álvarez-Román

González

et al. 2019

IEEE Trans.on Nanobioscience

View full text Add to dashboard Cite

In developing countries, the incidence of postharvest losses reduces the quantity and quality of food for human consumption and causes an economical damage along the food chain, especially, for primary producers. In this study, a multisystem coating (NC-EOt-C) based on pullulan and polymeric nanocapsules containing EO of Thymus vulgaris L. (EOt) was applied to increase the shelf life of table grapes (Vitis vinifera L.). The major components of EOt, chemically characterized by GC-MS, were o-cymene (32.68%), thymol (31.90%), and γ-terpinene (15.69%). The NC-EOt were prepared by nanoprecipitation and showed a particle mean size of 153.9 nm, a polydispersity index of 0.186, a zeta potential of −4.11 mV, and an encapsulation efficiency of 52.81%. The antioxidant capacity (DPPH and ABTS + methods) of EOt was maintained, or even improved, after its incorporation into NC. The shelf life study showed that grapes having the NC-EOt-C multisystem maintained their characteristics of color, firmness, TA, and SSC for longer time than those without the multisystem. NC-EOt-C multisystem acted as a barrier which reduced the metabolism of fruits. In addition, the compounds of EOt with antimicrobial activity avoided microorganism growth, while those with antioxidant activity reduced the oxidative stress induced during postharvest of grapes. Additionally, the polymeric structure of NC prevented the rapid evaporation of volatile compounds of EOt, increasing then their residence time on the fruit. Our study demonstrated that NC-EOt-C multisystem can be a viable alternative to preserve horticultural products for longer storage periods.

show abstract

Section: B Physicochemical Characterization Of Nc-eotsupporting

confidence: 93%

Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.)

Pina-Barrera

Álvarez-Román

González

et al. 2019

IEEE Trans.on Nanobioscience

View full text Add to dashboard Cite

show abstract

“…However, only 23% of bixin loss was observed in biscuit dough baked at 150°C for 30 min, showing that the matrix presents a considerable influence on the carotenoid stability. Many experiments about the encapsulation of carotenoids by polymers in the aim to enhance their thermal stability were already reported, and PLA is a widely used polymer in the field 31–33 . Our system might produce an effect similar to matrix encapsulation, where the bioactive compound is uniformly distributed over the formed biopolymer carrier system 34 .…”

Section: Resultsmentioning

confidence: 97%

“…Many experiments about the encapsulation of carotenoids by polymers in the aim to enhance their thermal stability were already reported, and PLA is a widely used polymer in the field. [31][32][33] Our system might produce an effect similar to matrix encapsulation, where the bioactive compound is uniformly distributed over the formed biopolymer carrier system. 34 PLA might offer a protection towards oxygen and heat.…”

Section: Thermal Stability Of Bixin During Film Processingmentioning

confidence: 99%

Polylactide films produced with bixin and acetyl tributyl citrate: Functional properties for active packaging

Stoll

Domenek

Flôres

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Packaging materials are decisive to preserve the quality and nutritional value of food. Polylactide (PLA) is a biodegradable polymer with adequate mechanical properties for packaging applications, but its moderate oxygen barrier properties and high UV light transmission hamper its performance as packaging for oxygen‐ and light‐sensitive products. Bixin, a carotenoid with coloring and antioxidant character, was used to improve the light barrier of PLA films plasticized or not with acetyl tri‐butyl citrate (ATBC). The films were subjected to thermal treatment mimicking polymer processing temperatures. Despite more than 74 wt% of bixin degraded during heat treatment, films were still blocking up to 95% of UVA and 90% of UVB transmission. Plasticizing PLA with ATBC accelerated up to six times the bixin release into a food simulant, which allowed to reach relevant concentrations for food preservation. In conclusion, bixin is a promising natural antioxidant and UV‐shielding additive of biodegradable packaging.

show abstract

“…PLA has been widely used in biomedicine, and it is considered to be a good material for preparing micron and nanoparticles because the particle size and shape can be controlled to meet the preparation requirements [100]. Using PEG-PLA-PEG nanoparticles as a delivery carriers for oral immunization enhanced mucosal uptake results in an effective immune response that preserves the antigenicity of the encapsulated HBsAg [101].…”

Section: Poly(lactic Acid)mentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

View full text Add to dashboard Cite

Polymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.

show abstract

Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Cited by 39 publications

References 24 publications

Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.)

Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.)

Polylactide films produced with bixin and acetyl tributyl citrate: Functional properties for active packaging

Applications of polymer-based nanoparticles in vaccine field

Contact Info

Product

Resources

About