Production and Characterization of Melon Sulfated Pectin (Cucumis melo var. acidulus) Nanoparticles with Anticoagulant Potential

Abstract

Samples of sulfated and non-sulfated polysaccharides were provided by the Department of Chemistry, at the Federal University of Ceara. Unfractionated heparin (Hemofol 5000UI / ml-Lote18030036) was purchased commercially. The Kits and the commercial kits used in the coagulation tests (APTT, PT and TT) were purchased commercially (Bios Diagnóstica ®). Poly (lactic-co-glycolic acid) (PLGA) with a 50:50 lactide co-glycolide ratio (MW 40-75 kDa) and poly (vinyl alcohol) (PVA) (MW 13-23 kDa, 87-89% hydrolyzed) were purchased from Sigma-Aldrich.