Production of NO and Oxidative Destruction of Proteins in the Placenta during Normal Pregnancy and Placental Insufficiency

Крукиер, И. И.

doi:10.1023/b:bebm.0000010954.15992.68

Cited by 4 publications

(1 citation statement)

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“…We do not know the functional impact of this down-regulation of mRNA expression of IL1RL1 and whether there is an overshooting compensatory expression later in development. IL-33 is the natural ligand for IL1RL1 and promotes angiogenesis by stimulating endothelial NO synthase [64]. Therefore, a decrease in NO production is directly linked to lowered expression of the receptor for IL-33 ( IL1RL1 ) and could reflect a supporting causative factor in the etiology of fetal growth restriction.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Changes Affecting Hedgehog and Cytokine Signalling in the Umbilical Cord: Implications for Disease Risk

et al. 2012

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BackgroundBabies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study. We investigated whether a transcriptomic signature of either birthweight or gestational age could be detected in umbilical cord RNA.MethodsThe gene expression patterns of 32 umbilical cords from Singaporean babies of Chinese ethnicity across a range of birthweights (1698–4151 g) and gestational ages (35–41 weeks) were determined. We confirmed the differential expression pattern by gestational age for 12 genes in a series of 127 umbilical cords of Chinese, Malay and Indian ethnicity.ResultsWe found that the transcriptome is substantially influenced by gestational age; but less so by birthweight. We show that some of the expression changes dependent on gestational age are enriched in signal transduction pathways, such as Hedgehog and in genes with roles in cytokine signalling and angiogenesis. We show that some of the gene expression changes we report are reflected in the epigenome.ConclusionsWe studied the umbilical cord which is peripheral to disease susceptible tissues. The results suggest that soma-wide transcriptome changes, preserved at the epigenetic level, may be a mechanism whereby birth outcomes are linked to the risk of adult metabolic and arthritic disease and suggest that greater attention be given to the association between premature birth and later disease risk.

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Section: Discussionmentioning

confidence: 99%