Drought is a main non-living factor that causes severe crop yield loss globally. Given the strengthening and reappearance of drought events and their impacts, it's important to deepen our understanding as a key to subsidizing mechanisms for drought training and mitigation plans. Pakistan is ranked maximum of the top 5 biggest cotton manufacturers, the seventh largest material producer international, and cotton contributes 10% to the country-wide GDP compared to the overall agriculture area GDP percentage of 18.9%. Cotton farming performs a tremendous role in presenting direct livelihood to 11 million farmers. The cotton crop, in particular, is confined to northern, imperative, and southern zones, with approximately 90 in keeping with cent of the area coming beneath 3 zones. Regardless of this, its cumulative, not apparent impact and multidimensional nature significantly impact the cotton plant’s morphological, physiological, biochemical, and molecular attributes with a detrimental impact on photosynthetic capability. Dealing with water scarcity, plants evolve various complicated resistance and edition mechanisms, including physiological and biochemical responses, which range with species stage. The sophisticated adaptation mechanisms and regularity community that improve the water stress tolerance and version in plants are briefly discussed. Growth pattern and structural dynamics, reduction in transpiration loss via altering stomatal conductance and distribution, leaf rolling, root-to-shoot ratio dynamics, root duration increment, accumulation of like-minded solutes, enhancement in transpiration performance, osmotic and hormonal regulation, and behind-schedule senescence are the techniques that are followed using cotton plant life underneath water deficit. Approaches for drought stress resistance we develop transgenic cotton plants which which can tolerate drought stress to improve cotton quality with good yield.