The aim of work is to explore influence of first fruitful insemination, service period and dry period to dairy productivity of Simmental cows. The research is aimed at studying the milk production of Simmental cows with different levels of reproductive qualities. The result of the research, a relation was established between the age of the first fruitful insemination, the duration of the service period, the duration of the dry period and milk production performance. It has been established that the age of the first fruitful insemination at 18-24 months has the most beneficial effect on subsequent milk production. The service period of 90-120 days has a positive effect to an increase in milk yield per 305 days of lactation, the longer service period negatively affects to the mass fraction of fat. With an increase in the duration of the dry period, the mass fraction of fat increases, but milk yield decreases. The influence of reproductive qualities to the milk protein is negligible. It was revealed that the age of the first insemination at 18-24 months is the most profitable for production. According to the results of the research, it can be judged that reproductive qualities, in combination with other factors, affect the milk productivity of Simmental cows.