Products containing biocides: perceptions and realities

Favero, Maktin S.

doi:10.1046/j.1365-2672.92.5s1.9.x

Cited by 12 publications

(3 citation statements)

References 9 publications

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“…The increased usage of biocides in products and formulations is undoubtedly driven by the demand to control and decrease the spread of the hospital-associated infections (HAIs) [56]. But the use of these products needs to be balanced between the benefit of controlling the spread of infections and the probable risk associated with its use, not only in terms of developing microbial resistance but also their toxicity and environmental contamination [1].…”

Section: Future Perspectivesmentioning

confidence: 99%

Potential impact of biocide adaptation on selection of antibiotic resistance in bacterial isolates

et al. 2020

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Background Antibiotic resistance in pathogenic bacterial isolates has increased worldwide leading to treatment failures. Main body Many concerns are being raised about the usage of biocidal products (including disinfectants, antiseptics, and preservatives) as a vital factor that contributes to the risk of development of antimicrobial resistance which has many environmental and economic impacts. Conclusion Consequently, it is important to recognize the different types of currently used biocides, their mechanisms of action, and their potential impact to develop cross-resistance and co-resistance to various antibiotics. The use of biocides in medical or industrial purposes should be monitored and regulated. In addition, new agents with biocidal activity should be investigated from new sources like phytochemicals in order to decrease the emergence of resistance among bacterial isolates.

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Section: Future Perspectivesmentioning

confidence: 99%

Potential impact of biocide adaptation on selection of antibiotic resistance in bacterial isolates

et al. 2020

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“…Antibacterial textiles have been on the market for many years [9], but their efficiency had not been proved earlier in normal use. To the authors' knowledge, this is the first study assessing the antibacterial properties of a hospital textile in real-life health care conditions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Properties of a Textile Product with Antimicrobial Finish in a Hospital Environment

Renaud¹,

Doré²,

Freney³

et al. 2006

Journal of Industrial Textiles

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The objective of this study is to evaluate the antibacterial activity of a textile product with an antimicrobial finish in real-life hospital conditions. Sixty antibacterial samples and nonactive controls are tested on garments worn by nurses during their working day. The number of colony forming units (CFU) is significantly lower on antibacterial textiles than on the nonactive ones. Moreover, the higher the contamination, the more this contamination was reduced, up to 50% reduction.

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“…Resistance to biocides is often referred to as tolerance (8). Biocides usually have multiple cellular targets, and their effects are concentration dependent and often evaluated in terms of their ability to reduce the numbers of viable microorganisms.…”

mentioning

confidence: 99%

Microscopic and Spectroscopic Analyses of Chlorhexidine Tolerance in Delftia acidovorans Biofilms

Rema

Lawrence

Dynes

et al. 2014

Antimicrob Agents Chemother

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The physicochemical responses of Delftia acidovorans biofilms exposed to the commonly used antimicrobial chlorhexidine (CHX) were examined in this study. A CHX-sensitive mutant (MIC, 1.0 g ml ؊1 ) was derived from a CHX-tolerant (MIC, 15.0 g ml ؊1 ) D. acidovorans parent strain using transposon mutagenesis. D. acidovorans mutant (MT51) and wild-type (WT15) strain biofilms were cultivated in flow cells and then treated with CHX at sub-MIC and inhibitory concentrations and examined by confocal laser scanning microscopy (CLSM), scanning transmission X-ray microscopy (STXM), and infrared (IR) spectroscopy. Specific morphological, structural, and chemical compositional differences between the CHX-treated and -untreated biofilms of both strains were observed. Apart from architectural differences, CLSM revealed a negative effect of CHX on biofilm thickness in the CHX-sensitive MT51 biofilms relative to those of the WT15 strain. STXM analyses showed that the WT15 biofilms contained two morphochemical cell variants, whereas only one type was detected in the MT51 biofilms. The cells in the MT51 biofilms bioaccumulated CHX to a similar extent as one of the cell types found in the WT15 biofilms, whereas the other cell type in the WT15 biofilms did not bioaccumulate CHX. STXM and IR spectral analyses revealed that CHX-sensitive MT51 cells accumulated the highest levels of CHX. Pretreating biofilms with EDTA promoted the accumulation of CHX in all cells. Thus, it is suggested that a subpopulation of cells that do not accumulate CHX appear to be responsible for greater CHX resistance in D. acidovorans WT15 biofilm in conjunction with the possible involvement of bacterial membrane stability.

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Products containing biocides: perceptions and realities

Cited by 12 publications

References 9 publications

Potential impact of biocide adaptation on selection of antibiotic resistance in bacterial isolates

Potential impact of biocide adaptation on selection of antibiotic resistance in bacterial isolates

Evaluation of Antibacterial Properties of a Textile Product with Antimicrobial Finish in a Hospital Environment

Microscopic and Spectroscopic Analyses of Chlorhexidine Tolerance in Delftia acidovorans Biofilms

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