ProEx C Stain Analysis in Recurrent Respiratory Papillomatosis

Bhandarkar, Naveen D.; Sims, H. Steven; David, Odile

doi:10.1177/000348941011900206

Cited by 4 publications

(2 citation statements)

References 17 publications

(21 reference statements)

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“…ProExC is a recently identified marker for high-grade squamous intraepithelial lesion, which is primarily confirmed in cervix. Few reports of ProExC expression in noncervical squamous lesions include vulvar squamous lesions, recurrent respiratory papilloma, Bowen disease, and actinic keratosis [23][24][25]. Our report is the first study of ProExC expression in ESIN and shows that it has similar sensitivity and specificity in detecting LGESIN and HGESIN to Ki-67.…”

Section: Discussionsupporting

confidence: 52%

Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia

Wang

Chandan

et al. 2011

Human Pathology

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Section: Discussionsupporting

confidence: 52%

Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia

Wang

Chandan

et al. 2011

Human Pathology

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“…[814] Diffuse ProEx C expression has also been reported in head and neck tumors, especially in respiratory squamous cell carcinomas. [15] In addition, strong ProEx C staining exhibited very high sensitivity and specificity for distinguishing normal/reactive hyperplasia from esophageal squamous intraepithelial neoplasia. [16] ProEx C immunoexpression has also been found to be significantly higher in melanomas compared to benign nevi.…”

Section: Introductionmentioning

confidence: 99%

Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

Tosuner

Türkmen

Arici

et al. 2017

J Cytol

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Aims:We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears.Settings and Design:Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) has been considered to have tight association with high grade intraepithelial lesions.Materials and Methods:A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells–undetermined significance (ASC-US), atypical squamous cells–cannot exclude high grade squamous intraepithelial lesion (ASC-H), low grade squamous intraepithelial lesion (LSIL), and high grade squamous intraepithelial lesion (HSIL) were included in our study.Results and Conclusions:ProEx C was positive in 14 of HSILs (100%), 3 of 19 LSILs (16%), 2 of 4 ASC-Hs, and none of ASC-USs (0%). The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.

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Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection

Hirai

Makiyama

Higuti

et al. 2012

Eur Arch Otorhinolaryngol

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A number of reports have investigated the relationship between laryngeal papilloma and human papilloma virus (HPV) infection. On the other hand, it is unclear whether the HPV infection is involved in the occurrence of pharyngeal papilloma. We hypothesized that HPV infection was involved in the occurrence of pharyngeal papilloma similarly to laryngeal papilloma. To verify this hypothesis, we investigated the presence of HPV infection. Furthermore, clinical manifestations of pharyngeal papilloma, which had rarely been reported, were discussed. A male-to-female ratio, solitary or multiple occurrences, and koilocytosis were examined in cases with pharyngeal papilloma. HPV DNA was examined with unfixed surgically resected specimens of pharyngeal papilloma. A screening test by the liquid-phase hybridization method was carried out for the HPV high-risk group (16, 18, 31, 33, 35, 39, 45, 51, 56, 58, 59, and 68) and HPV low-risk group (6, 11, 42, 43, 44). As a control, 15 cases with laryngeal papilloma for which the same screening test was carried out were employed. Pharyngeal papilloma occurred as a solitary lesion more often, whereas laryngeal papilloma occurred as multiple tumors more frequently. The HPV infection rate was 0% in pharyngeal papilloma cases, which was in stark contrast with 66.7% in the HPV low-risk group in laryngeal papilloma cases. Pharyngeal papilloma occurred as a solitary lesion in females more frequently. Contrary to our hypothesis, the involvement of HPV infection was unlikely in the occurrence of pharyngeal papilloma.

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ProEx C Stain Analysis in Recurrent Respiratory Papillomatosis

Cited by 4 publications

References 17 publications

Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia

Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia

Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection

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