Profile of lymphadenopathy: An institutional based cytomorphological study

Abstract

Introduction:Lymphadenopathy is one of the most common clinical presentations of patients attending the outdoor department of a hospital. Lymph node aspiration is of great value for the diagnosis of lymphadenitis, lymphomas, and metastatic carcinoma.Materials and Methods:In this study, we have reported the pattern of cytological diagnosis on fine-needle aspiration cytology (FNAC) of lymphadenopathy cases in Jammu region of Jammu and Kashmir state of India. The mean age of all the patients in this study was 21.67 years. The most common site of lymphadenopathy was cervical region (71.79%) followed by axillary region (11.11%).Results:Tubercular lymphadenitis (44.02%) was the single most common cause of lymphadenopathy followed by reactive lymphadenitis (42.64%), metastatic lesions (9.40%), and malignant lymphoma (4.70%). The sensitivity of 94.49%, positive predictive value of 96.26%, and diagnostic accuracy of 91.15% was achieved in our study.Conclusion:This study highlights the role of FNAC as a simple, inexpensive, relatively painless, rapid, repeatable, and reliable method of investigation for lymphadenopathy, especially in outpatient departments, peripheral hospitals, and dispensaries.

Analysis of FNAC in diagnosis of lymphadenopathy-a retrospective study from a regional cancer centre, Cuttack, Odisha

“…2 But in some other studies adenocarcinoma (40.91%) was the most frequent metastatic lesion encountered, followed by squamous cell carcinoma (27.27%) and breast carcinoma (9.09%). 5 Males had high risk for metastatic squamous cell carcinoma followed by metastatic adenocarcinoma which was comparable with Betsill et al 21 In our country, an accurate, early and timely accessibility as to the cause of lymphadenopathy is of considerable importance due to high prevalence of acute and chronic infective disorders and rapidly increasing incidence of neoplastic diseases. FNAC not only confirms the presence of metastatic disease but also gives clues regarding the nature and origin of primary tumor.…”

“…Studies from India and other developing countries shown benign disorders were more common than malignant disorders. 5 According to current results, malignant disorders were more common (51.27%) than benign disorders (48.27%). This finding was consistent with the study done by Steel et al, who found that the majority of their cases (59%) were malignant and (34%) were benign.…”

“…This finding was similar with the previous study. 5,6 Some other studies found a slight female predominance with male: female ratio1:1.2. Studies from India and other developing countries shown benign disorders were more common than malignant disorders.…”

“…It can arise either from benign or malignant causes depending on the geographical condition and socioeconomic setup. 5 It has been observed that lymphadenopathy can be seen in patients ranging from very early to advance age with various etiology. 5 In our study, the youngest patient presented lymphadenopathy was observed in 4-year female and oldest was 88 years males with mean age 48.57 years.…”

Clinicopathological Profile of Patients with Cervical Lymphadenopathy in a Tertiary Care Centre

“…Status of cervical lymph node is the most important prognostic factor in the treatment of patients with squamous-cell carcinoma of the head and neck 19,20 . In most of the studies, tuberculosis contributes to the main cause of the lymphadenopathy 18,[21][22][23][24] .…”