Profiles Associated with Sarcopenia in Hepatoma Patients Underwent Transcatheter Arterial Chemoembolization: A Data‐Mining Analysis

Hirota, Kaoru; Kawaguchi, Takumi; Hashida, Ryuki; Koya, Shunji; Bekki, Masafumi; Goshima, Norihiro; Yoshiyama, Teruhito; Otsuka, Takashi; Nozoe, Ryousuke; Nakano, Dan; Shirono, Tomotake; Shimose, Shigeo; Iwamoto, Hideki; Nishizaki, Takashi; Matsuse, Hiroo; Koga, Hironori; Shiba, Naoto; Torimura, Takuji

doi:10.17987/jcsm-cr.v3i2.66

Cited by 5 publications

(6 citation statements)

References 42 publications

(46 reference statements)

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“…Skeletal muscle mass was evaluated according to SMI using CT scans at the L3 . The CT scan used for this study was performed as part of HCC assessment.…”

Section: Methodsmentioning

confidence: 99%

“…We measured visceral fat area (VFA) using diagnostic CT scans at the umbilical level, as previously described . The CT scan images have already been performed for the assessment of HCC.…”

Section: Methodsmentioning

confidence: 99%

“…18,19 Evaluation of skeletal muscle mass and definition of muscle atrophy Skeletal muscle mass was evaluated according to SMI using CT scans at the L3. 20,21 The CT scan used for this study was performed as part of HCC assessment. SMI were calculated by normalizing the L3 skeletal muscle areas by the square of the height (m 2 ), respectively.…”

Section: Data Collectionmentioning

confidence: 99%

“…We measured visceral fat area (VFA) using diagnostic CT scans at the umbilical level, as previously described. 20,21 The CT scan images have already been performed for the Frailty and muscle atrophy in hepatoma patients 331 Hepatology Research 2020; 50: 330-341 assessment of HCC. The VFA was measured by the diagnostic software ImageJ.…”

Section: Evaluation Of Visceral Fat Areamentioning

confidence: 99%

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Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Hirota

Kawaguchi

Koya

et al. 2019

Hepatology Research

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Aim Muscle atrophy is a prognostic factor for patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). The Liver Frailty Index (LFI) is a simple physical function test; however, an association between LFI and muscle mass remains unclear. We aimed to investigate the utility of LFI for predicting muscle atrophy in CLD patients with HCC. Methods We enrolled 138 CLD patients with HCC (aged 77 years, female/male 34.8%/65.2%). Muscle mass was assessed by skeletal muscle index, and patients were classified into the muscle atrophy group (n = 109) or the non‐muscle atrophy group (n = 29). Physical frailty was assessed by LFI. The optimal cut‐off value of LFI for predicting muscle atrophy was identified by receiver operating characteristic analysis. Results In the muscle atrophy group, the prevalence of pre‐frail/frail was significantly higher than the non‐muscle atrophy group (87.2% vs. 58.6%, P = 0.0005). In the logistic regression analysis, being female and pre‐frail/frail were identified as independent factors associated with muscle atrophy (pre‐frail/frail; OR 3.601, 95% CI 1.381–9.400, P = 0.0088). In patients with normal grip strength, 71.1% of patients were pre‐frail/frail, in which 82.8% of patients showed muscle atrophy. Receiver operating characteristic statistics provided an area under the curve of 0.74, and an LFI cut‐off value of 2.94 for predicting muscle atrophy (sensitivity 88.06%, specificity 52.17%, accuracy 77.91%). Conclusions We showed that pre‐frail/frail was an independent factor for muscle atrophy in CLD patients with HCC. Furthermore, LFI predicted muscle atrophy with high sensitivity, even in patients with normal grip strength. Thus, LFI might be a useful screening tool for muscle atrophy in CLD patients with HCC.

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“…Skeletal muscle mass was evaluated according to SMI using CT scans at the L3 . The CT scan used for this study was performed as part of HCC assessment.…”

Section: Methodsmentioning

confidence: 99%

“…We measured visceral fat area (VFA) using diagnostic CT scans at the umbilical level, as previously described . The CT scan images have already been performed for the assessment of HCC.…”

Section: Methodsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Evaluation Of Visceral Fat Areamentioning

confidence: 99%

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Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Hirota

Kawaguchi

Koya

et al. 2019

Hepatology Research

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“…This gender difference could be accounted for a marked decrease of ΔSMI in female of the control group. In our previous study, skeletal muscle mass was also significantly decreased in female than in male HCC patients who underwent TACE (35). A possible reason for the gender difference is sex hormones.…”

Section: Discussionmentioning

confidence: 68%

Impact of cancer rehabilitation on the prognosis of patients with hepatocellular carcinoma

et al. 2020

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Sarcopenia is a prognostic factor for patients with hepatocellular carcinoma (HCC). Cancer rehabilitation (CR) improves patients' physical function and muscle mass. We investigated the effects of CR on the prognosis of patients with HCC. The present study was a prospective observational study, which analyzed 152 patients with HCC who underwent transcatheter arterial chemoembolization (TACE) between 2013 and 2016. Patients were classified into the CR (n=85) and control (n=67) groups. The effects of CR on muscle mass were evaluated by changes in the skeletal muscle index (SMI) before and after TACE. Independent factors associated with survival were evaluated by Cox regression analysis. Kaplan-Meier analysis was used to compare the survival rate between the CR and control groups. The difference in survival rate between the two groups was also examined after propensity score matching. SMI was significantly increased in the CR group compared with the control group. In Cox regression analysis, independent factors associated with survival were CR and Child-Pugh class A (estimate 1.760, 95% CI 0.914-3.226, P= 0.001; estimate 1.602, 95% CI 0.426-2.998, P= 0.0129). The survival rate was significantly higher in the CR group than in the control group (median 552 vs. 424 days; P= 0.0359). The survival rate was also significantly higher in the CR group than that in the control group after propensity score matching (median 529 vs. 369 days; P=0.0332). CR was associated with prolonged survival in patients with HCC who underwent TACE. Patients with cancer are recommended to maintain physical activity even during cancer treatment.

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The Effect of a Behavior Change Intervention with Feedback on Motor Function and Physical Activity for Patients with Hematological Malignancies Undergoing Chemotherapy: A Historical Controlled Study

Ishii

Natsuzako²,

Fukushima

et al. 2021

Palliat Care Res

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This study aimed to investigate the effectiveness of an intervention that applied a behavioral change approach to the usual rehabilitation for patients with hematological malignancies undergoing chemotherapy. Methods: Patients with hematological malignancies undergoing chemotherapy were divided into two groups: patients who underwent conventional rehabilitation (control group, n=12) and a counterpart who received a behavioral change intervention with feedback on motor function and physical activity (feedback group, n=13). We analyzed the changes in motor function and physical activity between the two groups from the start of rehabilitation to discharge. Results: There were a significant difference in walking speed between baseline and discharge. Changes in weekly steps were significantly higher in the feedback group than those in the control group. Conclusion:A behavioral change intervention with feedback on motor function and physical activity may improve voluntary exercise in patients with hematological malignancies undergoing chemotherapy.

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Profiles Associated with Sarcopenia in Hepatoma Patients Underwent Transcatheter Arterial Chemoembolization: A Data‐Mining Analysis

Cited by 5 publications

References 42 publications

Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma

Impact of cancer rehabilitation on the prognosis of patients with hepatocellular carcinoma

The Effect of a Behavior Change Intervention with Feedback on Motor Function and Physical Activity for Patients with Hematological Malignancies Undergoing Chemotherapy: A Historical Controlled Study

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