Profilin, a multi‐modal regulator of neuronal plasticity

Birbach, Andreas

doi:10.1002/bies.20822

Cited by 79 publications

(78 citation statements)

References 95 publications

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“…The most prominent outcome of expression profile positively correlating with factor 1 was related to the appearance of cytoskeleton organization proteins, such as profilin, fascin, coronin, and MTSS1. Multiple previous studies showed an essential role of profiling in long-term potentiation, associated cytoskeletal rearrangement, and importance in memory (127)(128)(129). Involvement of coronin in regulation of synaptic plasticity and cognition was also confirmed (130).…”

Section: Discussionmentioning

confidence: 63%

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation

Borovok

Nesher

Levin

et al. 2016

Molecular & Cellular Proteomics

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Spatial memory depends on the hippocampus, which is particularly vulnerable to aging. This vulnerability has implications for the impairment of navigation capacities in older people, who may show a marked drop in performance of spatial tasks with advancing age. Contemporary understanding of long-term memory formation relies on molecular mechanisms underlying long-term synaptic plasticity. With memory acquisition, activity-dependent changes occurring in synapses initiate multiple signal transduction pathways enhancing protein turnover. This enhancement facilitates de novo synthesis of plasticity related proteins, crucial factors for establishing persistent long-term synaptic plasticity and forming memory engrams. Extensive studies have been performed to elucidate molecular mechanisms of memory traces formation; however, the identity of plasticity related proteins is still evasive. In this study, we investigated protein turnover in mouse hippocampus during long-term spatial memory formation using the reference memory version of radial arm maze (RAM) paradigm. We identified 1592 proteins, which exhibited a complex picture of expression changes during spatial memory formation. Variable linear decomposition reduced significantly data dimensionality and enriched three principal factors responsible for variance of memory-related protein levels at (1) the initial phase of memory acquisition (165 proteins), (2) during the steep learning improvement (148 proteins), and (3) the final phase of the learning curve (123 proteins). Gene ontology and signaling pathways analysis revealed a clear correlation between memory improvement and learning phasecurbed expression profiles of proteins belonging to specific functional categories. We found differential enrichment of (1) Long-term synaptic plasticity is considered a cellular correlate of long-term memory (LTM) 1 . Contemporary understanding of memory formation is based on the initiation and maintenance of long-term synaptic plasticity (1-4), for which de novo protein synthesis is a vital requirement. De novo protein synthesis itself is secondary to activity-dependent changes in synapses that occur during learning processes. These activity changes trigger post-translational modifications of proteins initiating and sustaining multiple signal transduction pathways. In turn, these signaling pathways regulate changes in synaptic strength and connectivity by governing gene expression and protein translation (5-13). Depending on time elapsed since triggering of long-term synaptic plasticity, protein synthesis may be limited to the dendrites directly involved in the plasticity processes (14 -18). Multiple synaptic From the ‡Department

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Section: Discussionmentioning

confidence: 63%

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation

Borovok

Nesher

Levin

et al. 2016

Molecular & Cellular Proteomics

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“…Several studies have demonstrated that IgE from patients sensitized to one profilin binds to profilins from all other sources (40,41). In many cases, detection of IgE directed to one plant profilin indicates sensitization to other plant profilins (47,48).…”

Section: Discussionmentioning

confidence: 99%

Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2

Offermann

Schlachter

Perdue

et al. 2016

Journal of Biological Chemistry

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“…Profilin binds and sequesters G-actin and is therefore, by default, an inhibitor of nucleation and enhancer of depolymerization [5]. However, this role changes dramatically if formins or Ena/VASP are present and bound to the elongating plusends.…”

Section: Actin Dynamicsmentioning

confidence: 99%

Mathematical-Computational Simulation of Cytoskeletal Dynamics

Moura

Kritz

Leal

et al. 2016

Mathematical Modeling and Computational Intelligence in Engineering Applications

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Actin and microtubules are components of the cytoskeleton, and are key mediators of neuron growth and maintenance. Knowing how they are regulated enhances our understanding of neural development, ageing, degeneration, and regeneration. However, biological investigation alone will not unravel the complex cytoskeletal machinery. We expect that inquiries about the cytoskeleton can be significantly enhanced if their physico-chemical behavior is concealed and summarized in mathematical and computational models that can be coupled to concepts of biological regulation. Our computational modeling concerns the mechanical aspects associated with the dynamics of relatively simple, finger-like membrane protrusions called filopodia. Here we propose an alternative approach for representing the displacement of molecules and cytoplasmic fluid in the extremely narrow and long filopodia and discuss strategies to couple the particle-in-cell method with algorithms for laminar flow to model the two phases of actin dynamics: polymerization into filaments which are pulled back into the cell and compensatory G-actin drift towards its tip to supply polymerization. We use nerve cells of the fruit fly Drosophila as an effective, genetically amenable biological system to generate experimental data as the basis for the abstract models and their validation.

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Profilin, a multi‐modal regulator of neuronal plasticity

Cited by 79 publications

References 95 publications

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation

Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2

Mathematical-Computational Simulation of Cytoskeletal Dynamics

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