Profiling cancer testis antigens in non–small-cell lung cancer

Djureinovic, Dijana; Hallström, Björn M.; Horie, Masafumi; Mattsson, Johanna Sofia Margareta; Fleur, Linnéa La; Fagerberg, Linn; Brunnström, Hans; Lindskog, Cecilia; Madjar, Katrin; Rahnenführer, Jörg; Ekman, Simon; Ståhle, Elisabeth; Koyi, Hirsh; Brandén, Eva; Edlund, Karolina; Hengstler, Jan G.; Lambe, Mats; Saito, Akira; Botling, Johan; Pontén, Fredrik; Uhlén, Mathias; Micke, Patrick

doi:10.1172/jci.insight.86837

Cited by 94 publications

(113 citation statements)

References 76 publications

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“…To validate our findings we analyzed a reported 199sample NSCLC cohort profiled by RNA sequencing, 26 including 19 WHO 2004 LCLC cases and five LCNECs. WHO 2015 reclassification identified a similar proportion of LCLC marker-null cases in this cohort as in our discovery set (32% [n ¼ 6]).…”

Section: Validation Of Transcriptional Lclc Subgroupsmentioning

confidence: 72%

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Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Karlsson

Brunnström

Micke

et al. 2017

Journal of Thoracic Oncology

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Refined classification of LCLC has implications for diagnosis, prognostics, and therapy decisions. Our molecular analyses support the WHO 2015 classification of LCLC and LCNEC tumors, which herein follow different tumorigenic paths and can accordingly be stratified into different transcriptional subgroups, thus linking diagnostic immunohistochemical staining-driven classification with the transcriptional landscape of lung cancer.

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Section: Validation Of Transcriptional Lclc Subgroupsmentioning

confidence: 72%

“…Validation of gene expression subgroups was performed in data provided by Djureinovic et al 26 (see Supplementary Methods). Histological classification of the samples was updated according to the WHO 2015 guidelines as previously described.…”

Section: Gene Expression Analysis Validation Cohortmentioning

confidence: 99%

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Karlsson

Brunnström

Micke

et al. 2017

Journal of Thoracic Oncology

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“…Although numerous TAAs have been detected in NSCLC, 36 a few have been targeted by CAR T cells. 37, 38 The use of these few non-cancer-specific antigens, which include FAP, 39 EGFR, 40 mesothelin 41 and glypican-3, 17 has led to poor or undefined therapeutic outcomes in patients.…”

Section: Discussionmentioning

confidence: 99%

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

et al. 2017

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“…26,27 We found that tumours with the highest levels of Tfh were more likely to express the CT antigens MAGE-A1 and MAGE-A3, while the overall cancer testis antigen expression levels did not change (Fig S7). Conversely, CT antigens that had not previously been described to elicit T cell reactivity were not upregulated in Tfh high tumours.…”

Section: Resultsmentioning

confidence: 88%

Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma

Marshall

Enfield

et al. 2018

OncoImmunology

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T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens.

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Profiling cancer testis antigens in non–small-cell lung cancer

Cited by 94 publications

References 76 publications

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma

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