Profiling of volatile compounds in APCMin/+ mice blood by dynamic headspace extraction and gas chromatography/mass spectrometry

Kakuta, Shoji; Nishiumi, Shin; Yoshida, Masaru; Fukusaki, Eiichiro; Bamba, Takeshi

doi:10.1016/j.jchromb.2015.09.002

Cited by 8 publications

(1 citation statement)

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“…Upregulation of the pentose-phosphate pathway, another potential route for energy production, has also been detected using mass spectrometry-based metabolomics methods on HCT116 colon cancer cells (30). Metabolic consequences of genetic aberrations in CRC have been a focus of metabolomic studies, particular models of APC suppression which causes activation of β-catenin signaling (31, 32). A comprehensive study which examined urinary metabolites and gene expression on tumors from APC(Min/+) mice and patient tumors, revealed consistent metabolic changes associated with early tumor development.…”

Section: Metabolomic Studies On Colorectal Cancermentioning

confidence: 99%

Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics

et al. 2017

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Purpose of Review In this review we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to explore the role metabolomics can play in identifying exposures, assessing the interplay between co-exposures, and the development of personalized therapeutic interventions. Recent Findings Approximately 10 % of CRC cases can be explained by germ-line mutations, whereas the prevailing majority are caused by an initiating exposure event occurring decades prior to diagnosis. Recent research has shown that dietary metabolites are linked to a procarcinogenic or protective environment in the colon which is modulated by the microbiome. In addition, excessive alcohol has been shown to increase the risk of CRC and is dependent on diet (folate), the response of microbiome, and genetic polymorphisms within the folate and alcohol metabolic pathways. Metabolomics can not only be used to identify this modulation of host metabolism, which could affect the progression of the tumors but also response to targeted therapeutics. Summary This review highlights the current understanding of the multifaceted etiology and mechanisms of CRC development but also highlights where the field of metabolomics can contribute to a greater understanding of environmental exposure in CRC.

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Section: Metabolomic Studies On Colorectal Cancermentioning

confidence: 99%